Mold Causes Depression

November 21, 2010


Studies have confirmed a direct association between dampness in the home that causes mold to grow and an increased risk for depression. (Am J Public Health. 2007 Oct;97(10);1893-9) What is interesting to note is that the symptoms of depression persisted irrespective of whether the individuals living in the home perceived they had the power to abate the mold and improve their health.  What was not discussed was why we are susceptible to depression from mold exposure!

The toxins our immune system recognizes, such as mycotoxins, take action upon our nervous system. They disrupt the synthesis and balance of neurotransmitters that control brain speed (acetylcholine), mood and calmness (GABA and seratonin), and focus and processing speed and metabolism (dopamine). Imbalances in neurotransmitters will aggravate existing symptoms of:

  • low mood
  • fatigue
  • depression
  • weepiness
  • brain bog
  • anxiety
  • increased aggression and agitation
  • OCD
  • ADD
  • ADHD
  • impaired verbal
  • auditory or mental processing.

Toxins from mold also increase brain inflammation in susceptible individuals. Brain fog and processing disorders become easily aggravated especially because the temporal lobes of the brain are focal centers for these functions and are more susceptible to localized inflammatory attack from pathogens such as streptococcus and mycotoxins.


Immune Matrix has found clinically a high degree of correlation between immune sensitivity to molds, yeast, candida, and mycotoxins to the severity of eczema. With the suppression of the immune system in the presence of chronic mycotoxin exposure, pathogenic candida and bacteria can invade and take a foothold in the lining of the large intestine. This is how “leaky gut” is created. The pathogens bind to the lining creating microscopic holes in the intestinal lining. Undigested food “leaks” through these holes. The immune system begins to see these undigested food particles as “foreign” antigens and the creation of immune sensitivities, and chronic inflammation begins.

Overgrowth of yeast and other dysbiotic pathogens in the digestive tract cause intense sugar cravings. Sugars rob the body of B vitamins. Deficiencies in B vitamins increase the severity of eczema symptoms and delay skin healing. Dysbiosis also throws off one’s mineral balance making you more acidic; a prime environment favoring further pathogenic growth. Acid body terrain further imbalances core alkaline minerals in the body such as:

  • magnesium
  • molybdenum
  • selenium
  • manganese
  • zinc

all crucial for efficient liver detoxification pathway function. The result is increased extra-cellular toxic load and decreased cell membrane repair. Increased cellular toxicity increases immune inflammation, and antigen recognition causing ever increasing levels of food sensitivities to trigger more hives, skin rashes and eczema.


Women that suffer PMS in any of its forms are not efficient in degrading and excreting their estrogens through their liver. The detoxification process is called methylation. For those susceptible individuals, mycotoxins will accumulate in the liver and not be efficiently excreted. This results in increased toxic stress and accumulation to the liver. The more toxins that burden the liver, the less efficient the liver is at excreting all toxins and estrogen will tend to accumulate in the body as a result. This is how women become more estrogen toxic and increase their estrogen dependent cancer risk! Excessive estrogen creates:

  • breast tenderness
  • uterine and abdominal bloating
  • irritability
  • fatigue
  • sugar cravings
  • headache
  • red eyes
  • flushed face and digestive disturbances that include either episodic diarrhea
  • constipation or both
  • bloating
  • vomiting
  • nausea and water weight gain.


Certain strains of molds cause more neurological symptoms such as the dreaded black mold, stachybotrys. Many indoor, outdoor and food borne molds have mycotoxins that trigger immune inflammation which target the nervous system less intensely but lead to marked increase in symptoms a few hours after exposure. These symptoms include:

  • brain fog
  • fatigue
  • sleepiness
  • aggressive behavior
  • anger outbursts
  • irritability, and hyperactivity

Children seem to show more marked reactivity because their brains are developing and the coatings of their neurons are not completely methylated. Increases in toxic burden reduces the body’s ability to methylate. This reduces the body’s ability to coat and protect neurons. The result, toxins become more detrimental to nerves in the body, especially the brain.

In addition, many children have been exposed to streptococcus infection, aka strep throat. In many cases, the streptococcus then proceeds to live in the colon contributing to leaky gut, a silent infection. In fewer cases, the strep will attack the brain especially those with repeated ear infections. The temporal lobes are particularly sensitive to streptococcus infection and this area of the brain affects verbal and auditory processing. Streptococcus can continue to live in the intestinal system through adulthood. Overlay mycotoxins’ effect of increasing neurological inflammation and you can begin to see symptoms that did not previously exist in the presence of silent strep infection.

Mold – Chronic Fatigue

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Anna Manayan

Anna Manayan