OBesity Fat and Silent Inflammation

How much extra fat do you need to retain to be at risk for silent inflammation? Our body has white and brown fat, two types in fact. Brown fat protects our organs and white fat is what we see under the skin and muscles. Leptin is a hormone made by all fat cells, brown and white. But it can also be made by the liver, the pituitary, bone marrow, and some organs such as the stomach, breast tissue and ovaries.

When leptin functions properly, it inhibits appetite to counter the feeding hormone neuropeptide Y with short term and long term appetite control between meals to regulate digestion. When leptin is not made or our tissues are resistant to absorbing leptin, we can experience unending hunger, constant hunger, or hunger after eating! But leptin is a double edged sword as it also affects the rate in which we burn fat and thus our metabolic fires. The catch is that leptin circulates in direct proportion to body fat. The fatter you get the more leptin you will make which will result in your tissues becoming leptin resistant! Your tissues will begin to ignore leptin as a signal and appetite will gradually increase along with your fat cells.

How does leptin contribute to inflammation? One mechanism is that it fuels arteriosclerosis by stimulating vascular endothelial growth factor that results in inflammatory processes involving the lining of your arteries and veins. This is one mechanism of how weight gain causes more and more cardiovascular disease. Think of leptin like logs on a fire, you keep piling on the logs to increase the inflammation. (Arterioscler Thromb Vasc Biol. 27 (12): 2691–2698)

Another mechanism of fat to increase leptin is through estrogen. More fat cells means the storage of more estrogen which in turn stimulates more leptin production! (“Leptin”. Annu. Rev. Physiol. 62: 413–437) Weight gain can also affect sleep and result in sleep apnea. Sleep apnea causes increased leptin! However, the CPAP was found to decrease the leptin. (“Leptin, Obestatin and Apelin levels in patients with obstructive sleep apnoea syndrome”. Med. Sci. Monit. 17 (3): CR159–64, “Leptin and ghrelin levels in patients with obstructive sleep apnoea: effect of CPAP treatment”. Eur. Respir. J. 22 (2): 251–257) Finally, emotional stress not only stimulates us to eat to soothe our emotions but the stress also increases leptin levels! (Obesity (Silver Spring) 14 (10): 1832–1838)

We are now beginning to see that the same factors that throw off our metabolism, cause us to gain weight share the same markers for inflammation: sleep, emotional stress, estrogen levels, how much we eat and our body fat levels. In addition, fat cells produce

pro-inflammatory cytokines (cell-signaling molecules) that interact with leptin making this combination a double hit. (Leptin in the regulation of immunity, inflammation, and hematopoiesis”. J. Leukoc. Biol. 68 (4): 437–46) Furthermore, the same mechanism that one develops insulin resistance also contributes to leptin resistance. Both insulin and leptin increase inflammatory cytokins and promote IL-6 gene expression. (Endocrinology 149 (11): 5415–5422) Insulin increases leptin adding fire to fire. (Diabetes 45 (10): 1435–1438)

If the act of eating alone wasn’t enough to cause leptin secretion, which is needed, it’s the excessive secretion of leptins that is the problem. Certain foods cause excessive leptin excretion! Lectins are sugar binding proteins found in

  • beans
  • cereal grains
  • seeds
  • nuts

Lectins are known to stimulate excessive leptin. (BioMed Central Ltd.. doi:10.1186/1472-6823-5-10) Fructose also is linked to creating leptin resistance. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 295 (5): R1365–R1369)

In conclusion, if you thought gaining a few extra pounds each year was purely a cosmetic issue and obesity nothing more than political prejudice against a body type ideal, think again. If you want to ensure a productive life, resolve to take steps now to improve your diet. Eliminate the sodas, fruit juices, processed carbohydrate snacks, pastries and fancy syrup coffee drinks all loaded with excessive leptin producing nutrients. Begin to reduce your carbohydrate volume by fifty percent and replace it with fifty percent or more in vegetables. Eat low glycemic fruits and increase your lean proteins at every meal. Control your blood sugar with protein snacks. Those with insulin resistance or syndrome X can do two things. You can eat small meals every 3 hours that must include protein. Your first meal would be 9 a.m., 12 noon, 3p.m., 6 p.m., 9 p.m. for example. Watch the amount of carbohydrate you consume in each meal and your energy levels an hour after eating. If you find yourself feeling tired after a meal you are insulin resistant and need to begin to reduce the volume of carbohydrates you eat at any one meal. This will help your body to reduce its insulin excretion and help the tissues become less resistant and more responsive to insulin. Everyone in addition would benefit by takin BenaGene, a product that Immune Matrix stands behind to help reverse not only insulin resistance but the damaging inflammatory effects of advance-glycation end products that result from excessive carbohydrate and sugar consumption.

Improving what, how much and when you eat will sigificantly improve or damage your health. Therefore, take some time to audit your lifestyle and write down what changes you will make. Remember it takes 6 weeks to make a new change a habit so that it stops feeling foreign. As you institute these changes your body will be begin to detoxify and even go through cravings for the foods you know you need to cut back on. See these food cravings as a sign of how bad those foods are and know that with avoidance these cravings will go away…stay determined. Increasing and replacing your diet with more lean protein will help with hunger signals and cravings as does increasing your magnesium intake!

Immune Matrix couples its comprehensive computerized immune testing technology with state of the art GenotypeÔ nutritional consultation which identifies those foods that

create a genetic inflammatory signal to your body. That information gives its patients a comprehensive list of those metabolic nutrients, immune stimulants and other factors that are promoting hidden inflammatory based health issues. Short of such an evaluation, taking steps to improve your diet and blood sugar, balance your hormones, reduce your emotional stress, improve your sleep, loose the excess fat, and reduce hidden infection, you can do much on your own to slow and reverse hidden killing inflammation in your body.

Please note:
Information on this site is provided for informational purposes only and is not intended as a substitute for the advice provided by your physician or other healthcare professional. You should not use the information on this site for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment.

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Anna Manayan

Anna Manayan