Estrogen

2010/06/27
Published

The incidences of breast cancer have not declined despite routine mammogram testing and the increasing trend to use natural compounded hormones. One of the reasons is   doctors who prescribe hormone replacement therapy, whether natural or synthetic hormones, do not follow up and continue to monitor their patient’s hormone levels! Failing to watch your body’s reaction and accumulation of hormones in response to therapy can be deadly and lead you directly to the development of uterine and breast cancer as a result of elevated estrogen! In most cases there are no warning symptoms until you develop that lump in your breast or end up in your gynecologist office complaining of uterine bleeding, a warning sign for cancer in post-menopausal women! Don’t let you or your doctor’s apathy cause you to develop an estrogen based cancer.  

How Often Should I Have My Hormones Tested?

Your prescribing doctor should test their patients’ hormone levels regularly. Failing to do so can push their patients to the development of breast and uterine cancer. However, rather than blame, take responsibility in directing your care because assuming you are fine because the doctor assumes you are fine can result with an unpleasant surprise a year or more down the line!

At the beginning of any hormone therapy program, you should be tested within the first 60-90 days to determine how your body is reacting to the hormones. You cannot tell by how you feel! Thereafter, to be proactive get tested every 3 months if there is a history of cancer in the family, or if you have allergies, chronic fatigue, lyme disease, eczema, dysbiosis, or any other chronic inflammatory condition because it means that your liver detoxification pathways do not work their best. Adding any hormone therapy to a body that suffers chronic inflammation can easily result in estrogen dominance when your liver detoxification pathways are not properly supported with the extra load of exogenous hormones. If you are not suffering from any type of chronic inflammatory condition and your 3 month lab test after starting hormone therapy showed optimal ranges, then your next test could safely be put off for 4 months, but no longer.

If your doctor won’t run a test or he/she minimizes the need for testing then there is an affordable test you can obtain and do from home through www.immunematrix.com (Extended Postmenopause Panel – Diagnos-Techs, Inc./saliva SKU: SKU16269). The results take 2 weeks to come in and can then be communicated to your prescribing doctor to adjust your hormone dosages. You can also contact Diagnos-Techs, Inc. (http://www.diagnostechs.com) and look up a referral for a doctor affiliated with this laboratory in your area, who will then be familiar with this type of testing.

Testing within the first 3 months of starting a hormone program allows you to catch elevated estrogens, progesterone and testosterone before they increase your risk of cancer. Immune Matrix has seen cases in which a patient was only tested once in the year by a famous physician (too busy to follow up with all their patients, and the patient presumed by this doctor’s fame that they were covered) and that woman went on to develop estrogen based breast cancer by the end of the year as a result of elevated estrogens! Immune Matrix makes it a point of testing any patient on hormone therapy for this very reason. Make sure you don’t slip through the cracks with your doctor. Become educated and know your hormone levels. It’s easy to do.

The expanded Postmenopausal Hormone panel by Diagnos-Techs, Inc. offered online by Immune Matrix tests via saliva for: DHEA, Testosterone, Estrone, Estradiol, Estriol, and Progesterone and based on the ratio of the hormones, it calculates your Breast and Uterine Proliferation Index or risk! This is why this test is so valuable! The chart below is an example of the index you will receive and it is diagnostic for estrogen dominance. The chart also explains your risk factor for breast or uterine cancer.

Looking at the chart above, this particular patient had not been tested by her prescribing doctor after having been put on hormone therapy. Her DHEA was elevated at 25 when it should not have exceeded 10ng/ml. Her testosterone was elevated at 32 when it should not have exceeded 20pg/ml! Her estrone was greater than 100 and it should not have exceeded 64 pg/ml! Her Estradiol was 66 and it should not have exceeded 13pg/ml! Her estriol was in excess of 100 when it should not have been in excess of 38pg/ml! And her progesterone was greater than 2000, and it should not have exceeded 300pg/ml! This is why this patient was found to be estrogen dominant with no apparent signs but fatigue (caused by excessive progesterone). If she stayed on the hormone replacement program her doctor prescribed, her risk for breast cancer and uterine cancer would be greatly enhanced!

Another major problem with most hormone replacement therapy is the use of transdermal progesterone. Time and again Immune Matrix finds that the hormone is stored in fat tissue. This causes elevated progesterone levels which do not respond to PTA (pituitary-adrenal-thyroid) feedback loop, frankly because the hormone is locked in a fat cell. Excessive progesterone makes you sluggish and tired! This patient went to another doctor who gave her B12 shots for fatigue. This helped but this patient needed to get rid of the cause, excessive progesterone. This patient also needed to detoxify her excessive estrogen and testosterone and DHEA by proper methylation support for her liver until her hormone levels optimized. Thereafter, her progesterone should be changed to sublingual where it will not be stored by fat cells! The dosages of her other hormones will have to be adjusted and then she will have to be retested in 60 and no more than 90 days to make sure she stays in the optimal range. This is the best way to prevent the development of estrogen based cancers while on hormone therapy.

Another simple test that can be done is to have a blood test that checks your hormone levels and also tests LH (leutinizing hormone). LH increases as the pituitary senses estrogen dominance from the drop in bio-available progesterone. Remember that as women age, their failure to ovulate means they fail to make progesterone. Progesterone allows a woman’s cells to use estrogens. This is one main reason why breast and uterine cancers rise sharply in menopausal women, because their lack of synthesis of progesterone causes the estrogen to go unopposed by progesterone, thus they become estrogen dominant. Excessive estrogen irritates the cells of the breast and uterus and can cause proliferation of cancer cells as a result. If your LH is elevated, you need to be on an oral progesterone, preferably sublingual and you need more of it. As your progesterone levels optimize, your LH levels will drop to normal values.

Take the time to double check your hormone levels. Do not assume from your doctor’s verbal assurances unverified by lab work, or based on your doctor’s demeanor of authority over you, or based upon their reputation in the community that your doctor has you covered without verification with proper lab testing. And without proper lab testing you cannot know if your hormone therapy is throwing your hormone levels out of balance. The risk of not knowing can cause you to silently become estrogen dominant and lead you into a cancer diagnosis. This mistake can cost you your life!

Please note:
Information on this site is provided for informational purposes only and is not intended as a substitute for the advice provided by your physician or other healthcare professional. You should not use the information on this site for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment.

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Anna Manayan

Anna Manayan