How to Keep the Weight Off, Genetic Link

Immune Matrix searches the globe for effective research based natural products and extracts that assist the body’s metabolic functions. As part of Anna Manayan’s anti-aging and metabolic research into the mechanisms of key metabolic functions, she has come to know a company called Terrabiological, who put oxaloacetate on the market. Oxaloacetate, as a nutritional supplement is making groundbreaking inroads into helping metabolisms challenged by:

  • diabetes
  • dementia
  • Alzheimer
  • Parkinson’s
  • Syndrome X
  • athletic performance and energy optimization.

Now in a formula backed by scientific studies and ongoing research, inroads have been made to conquer childhood obesity and to assist adults to keep the weight off by helping optimize our gene function. We are proud to feature LeanGene as the product ingeniously targeting our fat cell metabolism.

LeanGene contains oxaloacetate which has been shown to

•        Mimic Calorie Restriction

•        Reduce the activity of genes associated with fat    production

•        Support Glucose & Triglyceride Metabolism

•       Acts as a Powerful Antioxidant

Gene Chip Studies indicate that LeanGene down-regulates the action of genes that create and store fat. The following genes were found to be down regulated:

Acaa1 30% Reduction
Fasn    30% Reduction
Ndufab1   20% Reduction
Pcx  30% Reduction

To order this product, please go to this link

Being on a Diet alters the expression of your Genes.

Gene chip studies have shown that being on a diet decreases the activity of certain genes involved in the creation and storage of fat. After you stop your diet, these Fat storage and creation genes kick into high gear, and the result is that you quickly gain back the fat you so recently lost frustrating your efforts to keep the weight off. This is called the “Rebound” effect. Research has shown that the rebound effect can be reduced with compounds that mimic the “Calorie Restriction” metabolic state such as are found in LeanGene.  Laboratory tests showed a 30% reduction in the activity of the “Fatty Genes” as compared to the test group– even though each group ate the same amount of food.  The net result: the LeanGene group weighed less, and had significantly less fat than the control group.

Use LeanGene to help turn-down your “Fatty Genes” after your diet. How? LeanGene helps keep the weight off by activating AMPK. AMPK is known as AMP-activated protein kinase and it is a protein enzyme that functions to regulate cell energy metabolism. It has been found that activation of AMPK improves blood glucose balance, cholesterol profile, and blood pressure in studies with insulin-resistant rodents. ( J Obes. 2011;2011:252817. Epub 2010 Dec 22, Handb Exp Pharmacol. 2011;(203):303-30, Diabetol Metab Syndr. 2011 Jul 20;3(1):16, Aging Cell. 2009 Dec;8(6):765-8. Epub 2009 Sep 30, J Obes. 2011;2011:252817. Epub 2010 Dec 22, AMPK as Target for Intervention in Childhood and Adolescent Obesity.University of Zulia, School of Medicine, Final Avenida 20, Edificio Multidisciplinario, primer piso, Maracaibo 4004, Venezuela. J Biol Chem. 2004 Dec 17;279(51):52934-9. Epub 2004 Sep 30)

Research suggests the mechanism of action for AMPK activation is similar to the effects of physical activity or those of calorie restriction calorie restriction by acting on multiple cellular targets. Furthermore,  AMPK activation has been found to decrease the stomach fat of insulin-resistant patients. This is ground breaking news for everyone trying to keep the weight off with lifestyle and diet. This fat is highly implicated in systemic inflammation.  This finding is so significant that drug companies are now targeting drugs to mimic the effects of AMPK activation in antidiabetic drugs, including the biguanides (metformin metformin ) and thiazolidinedione thiazolidinediones, as well as of insulin-sensitizing adipokines (e.g., adiponectin ). However, when a natural product is available, one can avoid the toxic stress and potential side effects of artificial drugs.

The Importance of Glucose Stability

LeanGene is designed to help support healthy blood sugar levels and increase the processing of sugars in your muscles. It does this on many different levels.

1. AMPK Activation

AMPK has been shown to reduce fasting glucose levels by driving the glucose to your muscles so that you can use the glucose for energy rather than fat production. When our muscles have glucose we can actually feel stronger and we have better stamina.

2. Increased Activity of Pyruvate Dehydrogenase

Pyruvate Dehydrogenase (PDH) is an enzyme in your body that allows glucose derived pyruvate to enter the Krebs cycle and generate ATP for your energy needs.  Oxaloacetate supplementation (LeanGene) has been shown to both increase the activity of PDH, and to decrease muscle fatigue.  Being able to burn more glucose to give you more energy is preferable to having the energy diverted to fat production and it helps you have more energy to stay active, keys to keeping the weight off. This product can help anyone suffering from low energy and chronic fatigue.

3. Increased Foxo3a Gene Activity – reduce sugar cravings

The Foxo3a gene is involved in glucose regulation.  LeanGene supplementation has been shown in gene chip studies to increase the activity of this gene by 70%, allowing for better glucose stability. Better glucose stability means you don’t go into a fat storage mode. It means you can keep the weight off better!  Individual case studies document a 55% reduction in glucose amplitude variability.  Decreasing low glucose conditions reduces sugar cravings while decreasing high glucose conditions decreases cellular damage.

With all this talk of AMPK activation, is this is natural process? Absolutely! AMPK activation occurs naturally in the body from reduced calorie intake (dieting) and by long term exercise, both of which will also help to reduce the activity of genes that create and store fat.  Diet and Exercise is the first line defense to keep the weight off. However, LeanGene can assist your body’s ability to prevent fat storage by activating AMPK during the time you are not dieting. LeanGene is an AFTER DIET nutritional supplement designed to reduce the “Rebound Effect” and make your weight maintenance more successful.

The adult recommended dosage is one capsule daily after your largest meal or as directed by a qualified health practitioner. Do not use during pregnancy and lactation. This formula is suitable for vegetarians.

Please note:

Information on this site is provided for informational purposes only and is not intended as a substitute for the advice provided by your physician or other healthcare professional. You should not use the information on this site for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment.

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Anna Manayan

Anna Manayan