Autism – Blood Type and Secretor Status

A huge challenge in the treatment of autism involves improving the child’s ability to detoxify. The children with the most severe symptoms are those that are most challenged to detoxify. Elevated liver enzymes and other lab values that would otherwise indicate stress on the liver rarely show up in even the most sensitive autistic child. However, Immune Matrix reports that in treating autistic children in the last dozen years there has been a noticeable and direct relationship seen between the severity of autism symptoms and the inability to efficiently detoxify. That correlation has a close association between blood type and secretor status.

The typical challenges Immune Matrix sees in these autistic patients are:

  •     increased reactivity to supplements, especially those containing sulfur and methionine

  •    increased reactivity to any attempt to stimulate excretion of heavy metals

  •  increased reactivity to Candida, yeast and bacteria die-off

  •  increased reactivity to molds and mycotoxins in food and die-off

There are many reasons which our blog will address concerning why someone cannot tolerate and metabolize sulfur, cannot excrete heavy metals, or becomes reactive to the die-off of an aggressive pathogen killing program. There is a common element among many of the most severe in this category. Their blood type and secretor status reveals they are non-secretors and in the most severe cases they are blood type A.

Research is revealing that the red blood cell plays a significant role affecting our metabolic and immune metabolism and thus pre-disposes us to certain health challenges. Most people are aware of the common blood groupings of A, B, AB and O. These groupings are based up a specific antigen on one’s red blood cell. The Lewis blood grouping identifies salivary antigens associated with whether your blood secretes a specific Lewis blood group antigen. This has been associated with the term “secretor” and “non-secretor”.

The “secretor gene” is associated with your red blood cell. It controls whether or not you “secrete” your ABO blood-type antigen into your bodily secretions of saliva, sweat, tears, semen and serum. If your red blood cell secretes its ABO blood-type antigen, you are classified a “secretor”. This is called the ABH antigen system. Why does it matter to be a secretor or non-secretor? While a majority of the world are secretors, a minority are “non-secretors”, and this has a significant effect upon metabolism and immune function. It has profound effects upon an autistic child already exhibiting positive genetic SNPs for defects in the methylation pathway, compounding the inability to secrete toxins when their ABH antigen system reveals they are also non-secretors.

Ongoing research is limited but it has revealed that non-secretors have lower levels of enzymes to metabolize fats, are more sensitive and prone to developing environmental sensitivities, and have weaker immune systems to yeast and parasites. They tend to develop inflammatory diseases such as:

  • arthritis

  • chronic infections

  • and gut inflammatory symptoms.

Research has documented non-secretors as having immune challenges to fighting off Candida. (FEMS Microbiol Immunol.1989:1:401-405)

For the autistic child, being a non-secretor puts you at a disadvantage because it means that your immune system will tend to be weaker at fighting dysbiosis, chronic yeast, bacteria, and Candida infections. Your child is more likely to develop and have severe chemical and environmental sensitivities that cause neurological and behavioral symptoms. Your child will be limited in tolerance to the type and amount of supplements it can take to improve neurological function, to kill off pathogens and to stimulate the excretion of heavy metals. Your child will be ultra sensitive to metabolizing drugs and herbal medications and supplements.

Immune Matrix has found that its most severe autistic patients are toxic and non-secretors (and blood type A). Being a non-secretor in and of itself means that the child’s supplement program must be very conservative and must take into account any genetic SNPs in methylation and sulfur metabolism. In addition, these children have to take on one protocol at a time. This means the child’s ability to process and excrete toxins must be addressed first and before undertaking gut repair protocols or chelation. This means that these children have to first be helped to digest and metabolize food by the elimination of food sensitivities and metabolic immune sensitivities associated with the metabolism of B vitamins, magnesium and other trace minerals. Eliminating immune triggers that block the body’s ability to methylate, to process toxins, will enable the child to excrete the byproducts of pathogen die-off programs, chelation programs and neurotransmitter supplement support, all of which the child would otherwise not tolerate due to their inability to “secrete” toxins.

Being a non-secretor means that one is limited in their ability to process toxins. The combination of supplements and prescription medication in the form of anti-biotics can set the autistic child back and drive their symptoms deeper into the autism spectrum. These children have more sensitive digestive tracts and the form of supplementation often makes all the difference between a pill that is ground versus a liquid supplement. Anything taken in has to be detoxified. The combination of processing many supplements as is common in the DAN protocols, combined with taking some type of heavy metal chelator, along with an anti-fungal remedy to kill of dysbiotic flora can easily overload a non-secretor’s ability to excrete toxins.

What can you do if you suspect that your autistic child is having trouble taking multiple supplements, is reactive to heavy metal chelators, or acts more aggressive or distracted while taking a prescribed protocol? Find out your child’s blood type and also find out if your child is a non-secretor. Kits can be ordered online at:

For blood typing: (this is a finger prick test you can do at home)

For secretor status: (this is a saliva test that is sent to a specialized lab)

Identifying if your autistic child is a non-secretor is a once in a life time needed test that will enable you to know if your child will need to monitor his/her supplement program, medication program and diet to enable the child to process and excrete at a slower rate than secretors. These children need additional drainage support as well as essential nutrients, preferably liquid that directly fuel their methylation pathways. Their bodies do better processing one program at a time, such as eliminating dysbiotic bacteria first, or yeast and candida, all separate from eliminating heavy metals, or focusing on building up certain neurotransmitters.

Working with an experience practitioner knowledgeable in genetic variant SNPs in the detoxification pathway, the pitfalls of chelation for non-secretors, and other such challenges specific to non-secretors will help you tip toe around some of the pitfalls in treating autism that threaten to stop their progress. Knowing if your autistic child is a blood type A and a non-secretor will help you prevent severe side effects and red flag your child for more intensive monitoring and pacing of any treatment protocol.

Please note:
Information on this site is provided for informational purposes only and is not intended as a substitute for the advice provided by your physician or other healthcare professional. You should not use the information on this site for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment.

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Anna Manayan

Anna Manayan