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2010/02/28
Published
Two consistent issues that plague patients with chronic fatigue is blood sugar regulation and inefficient or sick mitochondria. Blood sugar regulation becomes an issue with those suffering from chronic fatigue because adrenal exhaustion weakens the body’s ability to regulate blood sugar. As a result the patient becomes more hypoglycemic over time and more intolerant to digesting carbohydrates. It turns into a vicious cycle whereby eating some carbohydrates makes you more tired and that in turn weakens your adrenals. It becomes a downward spiral. As the patient further reduces their consumption of carbohydrates their brain cries out for glucose and not receiving what it needs, more fatigue is created.
We have found a very promising supplement called benaGeneTM . This produce supplies the body with bio-identical human metabolite oxaloacetic acid (oxaloacetate in water) which helps to improve energy, improve sleep, reduce the ability to create and store fat, reduce cravings and reduce blood sugar.
Clinical trials using oxaloacetate have documented significant glucose level reductions in diabetic patients. A separate study in non-diabetic patients documented a reduction in the amplitude of glucose swings, allowing better overall blood sugar management. No negative side effects were reported. Although benaGeneTM lowers high glucose levels, it does not cause hypoglycemia (abnormally low glucose levels) in non-diabetic patients. Studies are underway that hold promise in showing it as effective as the drug Metformin but without the side effects.
Immune Matrix had some of their athlete patients take benaGeneTM and it was reported that these patients had improved stamina and cardiovascular endurance. Also noted were better blood sugar levels throughout the afternoon when taken at noon, reduced appetite, improved satiety, clearer thinking.
The other factor common to chronic fatigue patients is sick mitochondria. What is meant by this term is that these unique cells stop producing ATP the energy molecule the body needs to run on and/or stop producing the precursors that lead to the production of ATP such as NAD/NADH. The only previous way of getting around this problem was to supplement the body with sublingual NADH.
However, benaGeneTM , has shown so much promise that a study is about to begin at UC San Diego & the FDA involving the effects of benaGeneTM and mitochondrial function. What is currently understood about oxaloacetate is that this bio-identical human metabolite also increases NAD+/NADH ratio. Within the last five years, there have been several studies by major universities documenting that an increase in the NAD+/NADH ratio results in statistically significant increases in lifespan and health-span in laboratory animals. Equally as exciting, this same increase in the NAD+/NADH ratio has also been shown to increase individual human cell lifespan in vitro.
If you would like to try this product, it can be purchased online at www.ImmuneMatrix.com. Immune Matrix recommends patients to take one pill at lunch with their meal and one at dinner. If a patient is diabetic or is on diabetic medications, patients are advised to check their blood sugar levels between each meal and consult their prescribing physician before altering any prescription dosages in response to continued reduction in blood glucose levels. We at Immune Matrix think that benaGeneTM holds a lot of promise in helping patients improve their blood sugar regulation, strengthen their adrenal function as a result, reduce circulating sugars that would otherwise feed pathogens in the body, and help restore mitochondrial metabolism.
BenaGeneTM works through the energy sensor AMPK to mimic the calorie restricted state and activate genes that repair DNA and cellular structures.
Please note:
Information on this site is provided for informational purposes only and is not intended as a substitute for the advice provided by your physician or other healthcare professional. You should not use the information on this site for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment.
Hi,
I am a representative of Terra Biological– we are the scientific company behind benaGene. While we are pleased that the doctors at Immune Matrix LLC have taken a great interest in benaGene, we need to inject a note of caution here. benaGene is a nutritional supplement and does not diagnose, treat, prevent or cure any disease. While we have received anecdotal reports of various conditions that have improved with benaGene supplementation, we stress that we have not performed clinical trials on chronic fatigue syndrome patients nor mitochondrial disease patients. The clinical trial for diabetic patients was performed with sodium oxaloacetate which is very slightly different than the oxaloacetic acid which is provided in benaGene. So what is the science behind benaGene you may ask?
We have determined that oxaloacetate supplementation increases lifespan by mimicking some of the same molecular pathways as calorie restriction. The increase, as measured by short lived animals, is 25% (p < 0.001). (See our 2009 peer-reviewed articles in Aging Cell and in Open Longevity Journal). We have not measured the increase in lifespan in humans, as we would need 130 years to perform a full test. Note that calorie restriction has also not been proven to increase lifespan in any human subjects, however recent studies with monkeys over a 20 year period have shown increase in lifespan and health span with calorie restriction.
As a nutritional supplement, we present benaGene as a calorie restriction mimetic for anti-aging based on our work in animals. Any other use at this time is unproven.
Interested parties may also go to our website for a fuller literature review on the findings of oxaloacetate supplementation in humans and animals. If you do purchase our nutritional supplement benaGene from our website at www.benaGene.com , please use the discount code “Manayan33” during checkout to receive a 10% discount on your purchase.
Thank you so much for your interest in benaGene.
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2010/02/27
Published
This article is a general guideline for those feeling chronic fatigue and not knowing whether they should look at thyroid function as a contributing cause. In the case of thyroid function we could be talking about the cart before the horse because with chronic infection or chronic stress, thyroid function can become inhibited. Therefore, just because your search may lead you to a positive finding of “low thyroid function”, does not mean you have found the cause of your chronic fatigue!
The thyroid, just like the adrenal glands can be the canary in the mine field. Their function starts becoming imbalanced as a consequence to chronic exposure to environmental toxins, heavy metals, molds toxins, silent bacterial infections in the gut, chronic undiagnosed viral infections, viral attack to the thyroid, lack of hormonal feedback support as in the Pituitary-Thyroid-Adrenal Axis, and auto-immune antibodies developed against your thyroid, as well as chronic stress!
It is highly advisable to know exactly what your thyroid is doing if you are feeling persistent fatigue. Have a blood test done that includes the following: TSH, free T3, reverse T3, thyroglobulins, T4. Many doctors unfortunately still do not test for free T3 and miss a majority of low thyroid conditions as a result. One can have normal values in everything and then find their free T3 is low, and thus they do not have sufficient unbound thyroid hormone to use. In addition, thyroglobulines are not routinely tested and if that were done, auto-immune thyroid conditions could be caught in their early stages and reversed before they become chronic Hashimotos.
When it comes to the thyroid and the adrenals, not all glands are created equal in our body and some are stronger and some are weaker just by nature. Under stress, one may become symptomatic first. Lets look at the correlations and bear in mind that these are very general guidelines only to help you evaluate the need for serum thyroid hormones and salivary cortisol biorhythm levels. Bear in mind also that if you do test for thyroid and adrenal and don’t test for the other, patients do better in therapy when treatment modalities include support both glands to optimize their levels. It is a common medial oversight for practitioners to treat the thyroid and ignore testing and treating the adrenals.
Weight gain: When the adrenals are involved the weight gain is generally first to the belly and hips, while with thyroid it is more generalized, and is hard to loose in both cases.
Eyes: When thyroid is involved one can see the eyes as full or puffy with or without bags, whereas with adrenal issues the eyes can be more sunken when severe, and may have dark circles, and more likely to suffer night blindness and sensitivity to bright light.
Eyebrows: With low thyroid function people tend to loose the outer third or half of their eyebrows, either totally or they get thin. This does not happen with adrenal issues.
Hair: The adrenals tend to make the hair thinner and dry, and sparse on the forearms and lower legs. The thyroid also can cause hair to fall out easily, with a tendency for coarseness and even change in color to the hair prematurely.
Nails: With thyroid issues the nails thicken; with adrenal issues they get thin and brittle and in both cases they break easily.
Skin: With thyroid issues wound healing is delayed, sometimes with easy bruising, and tendency for the skin to thicken not thin, and be oily with a tendency for fluid retention. With adrenal issues the skin tends to be dry, thin and collagen can become depleted leading to wrinkling of skin especially seen over finger pads, with dry skin and an inability to hold one’s water. In mixed thyroid and adrenal conditions you can see a combination of thin, dry, poor healing, bruising skin!
Ligaments: With thyroid issues you see a decrease in flexibility. Their pains tend to focus on joints, muscles and the lower extremities. With adrenal issues you tend to see lax or loose ligaments and very flexible people, those with flat feet, being double jointed and may suffer strains and sprains easier. They tend to suffer headaches, migraines, and carpal tunnel syndromes.
Temperature: Thyroid conditions tend to have stable but low temperatures, below 98.6. Adrenal conditions tend to have problems with regulating their temperatures, suffering when its hot and being too cold when its cold and can also have lower body temperature that fluctuates more often. Thyroid issues tend to tolerate heat over cold. Adrenal issues tend to tolerate cold over heat.
Sweating: This is tricky because in the early stages affecting the glands, sweating may be excessive for adrenal issues but once they become chronic the patient tends to stop sweating. Thyroid issues can have a tendency to increased sweating.
Emotional Reactivity: Adrenal conditions tend to push the patient towards over-reactivity while the thyroid patient tends toward under-reactivity.
Immune Function: Adrenal conditions tend to push the immune system into a hyper-vigilant state resulting in allergies, food and environmental sensitivities, and auto-immune problems. As a result, adrenal conditions tend to make the patient more sensitive to drugs and supplements. Thyroid conditions tend towards the opposite, and as a result tend to suffer chronic infections such as sinus, bladder, skin and the like.
Sleep: If sleep is impacted, thyroid issues tend to cause a person to suffer from sleepiness, narcolepsy, sleep apnea or un-refreshed sleep in general. Adrenal issues tend to cause more often insomnia, the inability to fall asleep, to have night time munchies, to feel wired and tired and un-refreshed sleep as well.
Energy: A thyroid condition can make the patient feel sluggish, and have low motivation to do things. An adrenal condition can cause fatigue and sleepiness within an hour or two after a carbohydrate containing meal. It can cause the patient more likely to feel exhaustion with bouts of energy as in “wired and tired” where the patient can’t persevere, and recovery after exertion is delayed.
The Legs: If the patient suffers from edema in the legs it is more likely to be non-pitting edema for the thyroid condition, whereas with the adrenal condition the patient fatigues more from standing, walking is easier. But leg and body pains are common in both!
Blood pressure: The adrenal condition tends to have blood pressure that runs low 80/50 to 110/70 and tends to get light headed when getting up to stand from sitting or lying down. With thyroid conditions the blood pressure is normal to high and can have problems with regulating blood pressure on drugs.
Digestion: Mal-absorption is seen more often with those having adrenal problems over thyroid, and carbohydrate and salt cravings are common; whereas, fats are craved more with those challenged by thyroid issues. Food can pass through the bowels quicker with those that are adrenal challenged, while those suffering from thyroid issues can have a tendency for constipation.
Cholesterol: Adrenal issues can cause cholesterol to be low normal while thyroid issues can elevate cholesterol and have it be hard to manage without addressing the thyroid. The HDL tends to be higher with adrenal issues and lower with thyroid issues. The cholesterol/HDL ratio for adrenal issues tends to be higher at 4.0 + while with thyroid is is under 4.0 in general.
Serum Potassium: A blood potassium tends to be under 4.0 for thyroid issues and over 4.0 for adrenal issues.
Serum Sodium: A blood sodium level of over 140 is more common among thyroid issues and under 140 for adrenal issues.
DHEA: DHEA affects and is affected by adrenal issues.
Testosterone: This hormone will be affected in some cases with adrenal issues and will tend to be lower than normal.
Blood Type: Adrenal issues seen more in blood type A; thyroid is more Type O.
Platlets: Adrenal issues will see platlets under 200 and thyroid, over 300.
For access to salivary cortisol testing, go to the online store at www.ImmuneMatrix.com and order a Flex Matrix Cortisol kit. The price includes a consulation with a primary care provider to help guide you in your therapy options and from there you can obtain a requisition form to also have serum thyroid values tested. This is the best place to start to pin down what glands will need support while you then proceed to find the underlying cause(s) exhausting your thyroid/adrenals.
Please note:
Information on this site is provided for informational purposes only and is not intended as a substitute for the advice provided by your physician or other healthcare professional. You should not use the information on this site for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment.
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2010/02/27
Published
HOW DO THE ADRENALS IMPACT CHRONIC FATIGUE?
Our body has a hormonal rhythm of cortisol that varies depending on the time of day. Too much cortisol and we feel wired and tired. Too little cortisol we feel low energy and listless.
Under acute stress, our body produces more cortisol to help us get through an acute stage of stress. If the stressor persists our adrenals continue to output extra cortisol. The problem with prolonged cortisol output is that it creates insulin resistance. You won’t become diabetic necessarily but you will begin to gain fat, especially around the middle and you will start to feel more tired after a carbohydrate containing meal. Some people feel so sleepy after eating carbohydrates that they have to take a nap!
Depending upon what time of day our cortisol stay high, we can suffer cravings for sweets in an effort to boost our low energy, followed by fatigue. Some turn to coffee to boost their energy, only to exhaust their adrenals eventually as the adrenals begin to fail to respond to the caffeine stimulus.
The flip side begins to occur as the adrenals become fatigued and lower cortisol output occurs during certain parts of the day. During those low cortisol episodes, we experience trouble with maintaining our blood sugars. We might not be hungry in the morning and can’t fall asleep without eating before bed! Low cortisol values also contribute to a weakened immune system, allowing low grade infections to become chronic.
HOW CAN I KNOW IF MY CORTISOL IS OFF?
The best way to determine where your cortisol values are during the day is to do a saliva test. There is a cortisol saliva test available online store at www.ImmuneMatrix.com
that includes a practitioner’s consult on the findings. It takes two weeks to get the test results and knowing what time of day one’s cortisol is high and/or low, as it can be both high and low in a day, is essential for boosting one’s immune system function, improving one’s blood sugar regulation and optimizing one’s energy in a natural manner.
HOW CAN THE TYPE OF FOOD I EAT AFFECT MY ADRENALS?
Those with low cortisol functions need to minimize carbohydrates. If you feel tired after a meal then you have eaten too much carbohydrates for your metabolism. One needs to eat more frequent and smaller meals and more protein as snacks to strengthen the adrenal glands.
Those with high cortisol values need to avoid stimulants such as coffee, coke and overstimulation during the times when the cortisol values are high. If the value is high before bed, one needs to avoid family arguments before bed, reduce time on the computer and TV before bed and begin to do relaxing things to calm the body. This takes time and lifestyle changes to make long term changes in one’s adrenal function.
Please note:
Information on this site is provided for informational purposes only and is not intended as a substitute for the advice provided by your physician or other healthcare professional. You should not use the information on this site for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment.
2010/02/27
Published
In the 10+ years that Anna Manayan has been treating chronically ill patients certain common factors come into play that affect the syndrome called Chronic Fatigue. She is currently treating chronically ill patients at her clinic Immune Matrix which located in Milpitas California Please check her clinic’s website at http://www.immunematrix.com . This is a summary of my interview with her.Â
DETOXIFICATION PATHWAYS:
One does not have to have elevated liver enzymes to have a compromised detoxification pathways. Many patients have gone to their doctors, had blood tests run and were told their liver enzyme were fine, but these same patients knew that every time the tried to take a chelator to excrete heavy metals from their body, or take antibiotics, chlorella, or even a homeopathic or herbal detoxifier they felt even sicker. Why is that?
Both Western and Integrative medicine agree that the more compromised the liver’s ability to break down and bind circulating toxins (food metabolities, pathogen metabolities, drug metabolities, metals, pesticides, herbicides, petrochemicals from our air and food and water) the more compromised the immune system becomes. You don’t need to have elevated liver enzymes to have compromised liver detoxification pathways. The key involves the function of the immune system.
The more chronically ill a patient, the more likely their immune system has developed a “recognition” to a key detoxification metabolite. Most learned patients are aware that there are genetic defects called SNPS that increase their activation when the body is in a higher state of inflammation but one does not need to have genetic SNPS alone to have compromises in their ability to detoxify. A classic example of a detox pathway issue involves the immune system recognizing methionine, a simple amino acid! This prevents the patient from taking in methyl donors from their supplements like DMG, TMG, NAC, etc.. But the problem is usually more extensive than just having an immune recognition for methionine, and it involves the metabolites from methionine and the methylation pathway and other key detoxification pathways that also involve glutathione.
This sounds rather complicated but it is largely reversible when it involves immune recognition of a metabolite. Immune Matrix has developed an extensive database to test patients for the minute details involving their detoxification pathways. As a result, patients who cannot chelate, cannot take supplements, cannot take sulfur donors, methyl donors, cysteine donors, L-tryptophan, GABA precursors, and the like are able to get treated and begin the excrete toxins that their body has locked within their tissues.
How does a patient know if their detox pathways are functioning better? Immune Matrix uses urine and fecal labs and BioImpedence testing to determine the type and level of excretion of toxins and to determine whether the toxins are locked “within” the cells, “between” cells or locked in fat cells. Advanced computerized testing also gives us generalized information as to the nature of the toxic burden, be it food metabolities, heavy metals, pesticides or dead pathogens the body as not yet eliminated.
How long does it take for a patient to determine if their detoxification pathways are compromised? A 30 minute computerized exam is sufficient in most cases to determine the extent and nature of the toxic burden affecting a patient.
Why is it important to know if my detoxification pathways are working uninhibited by my immune system? In order for the body to continue process antibiotics, herbal and homeopathic remedies, it has to be able to eliminate them efficiently. If you can improve your ability to detoxify, and Immune Matrix specializes in taking on cases sent by other practitioners where the patient can’t take anything anymore without reacting, and thus flunks out of the doctor’s treatment protocol, then a patient can return to their treatment modality with regained vigor.Â
CHRONIC INFECTION:
How does chronic infection play a part in chronic fatigue? We at Immune Matrix have consistently seen the presence of long standing viral and bacterial infections such as Epstein Barr, Rocky Mt. Spotted Fever, HHV-6, cytomeg.virus, strep. and even lyme co-infectants and lyme disease pathogens to name the most common big hitters.
Are these pathogens regularly tested by doctors? No because in most part western medicine feels that there is nothing that can be done to eradicate them from the body. In some cases a patient is put on an anti-viral medication to suppress it, but we have found that this inhibits the body in its ability to excrete the pathogen and reduce its viral load. Even in the case of strep found living in the digestive tract, most doctors do nothing as this strep is anti-biotic resistant.
How do these pathogens contribute to chronic fatigue? Generally speaking stress weakens the immune system and allows the pathogen to gain a foothold in the body. Over time the immune system weakens to identifying the presence of the pathogen, like princess sitting on the pea, over time it stops noticing the irritation. Patients will go through cycles of feeling better but not their old self and then feeling weak and tired again. This is because the pathogen gains a foothold and the body begins a compromised fight that does not completely eradicate the pathogen but only keeps it under check. Over time this round robin cycle fatigues the immune system and also weakens the adrenal glands causing adrenal fatigue and exhaustion. Once the adrenal glands become exhausted, the don’t repair themselves easily or overnight and never when a pathogen continues to co-exist to the extent that it causes chronic fatigue.
How do I know if I have one of these pathogens? Blood tests are available with many labs to screen for common chronic fatigue viral pathogens. However, we at Immune Matrix do a computerized screening to help determine what blood tests are needed to save patients the cost of expensive labs and from missing a commonly overlooked pathogen. We see this time and time again!
Does Immune Matrix have a method to eliminate chronic fatigue pathogens? Yes we do. We have a proprietary array of serial dilution homeopathics and herbal blended tinctures that have proved over time in label tests to be effective in eradicating these pathogens. We also have a treatment protocol to rebuild adrenal strength as the pathogens are eliminated.
Please note:
Information on this site is provided for informational purposes only and is not intended as a substitute for the advice provided by your physician or other healthcare professional. You should not use the information on this site for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment.
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