VITAMINS AND MINERALS � Chronic Fatigue and Nutrition

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WHAT TYPE OF MAGNESIUM SHOULD I TAKE?

2010/06/22
Published

Page 6 of 6 (The Magnesium Deficiency Epidemic)

In Parts 1 and 2 we discussed why most of us are magnesium deficient and those lifestyle factors that cause us to burn magnesium at a faster rate. In Parts 3 and 4 we discussed why magnesium plays a crucial role in our staying healthy and energetic. We also learned which type of conditions are made worse with magnesium deficiency and how magnesium deficiency can play a central role in our developing other conditions. In Part 5 we discussed how to determine our relative magnesium needs and how to get tested for intracellular magnesium. Here we will guide you to choose foods high in magnesium as a regular part of your diet. Empowered with this knowledge, you will be able to begin to restore the mineral balance so crucial to proper metabolic function.

Experiment with different types of magnesium to determine what works best with your body. Taken with or without food and spreading the dosages out during the day, can have a huge benefit in your body’s ability to absorb magnesium. Those who reach bowel tolerance too soon and are unable to take sufficient magnesium supplements should consider also adding a transdermal magnesium, available online a www.immunematrix.com called MagneDerm™.

Magnesium that is chelated, meaning bound to other minerals, may contain ionized unbound inorganic magnesium. This is not easily absorbed by the body. It is better to avoid unbound material to improve absorption.

Some recommended brands include:

Advanced Medical Nutrition, Inc (AMNI) Amino Mag, Solgar Magnesium Glycinate, Albion chelate also has a patented magnesium, J.R. Carlson Magnesium Glycinate or Immune Matrix’s favorite, a powdered magnesium that has little to no taste and will not deplete your body of L-glutathione, taurine, B6, and thiamin. This is why Immune Matrix favors the Magneleuvers brand because it does not deplete the body of other essential nutrients to metabolize magnesium! Magneleuvers is manufactured by SEROYAL out of Belgium and this powdered magnesium is very bioavailable and easy to add into any liquid drinks with hardly any taste of its own. It is available online at www.immunematrix.com. According to Immune Matrix, it is a top performer among their supplements tested on the most chronically ill patients with severely compromised digestive tracts for both children and adults. Patients needing to replenish their magnesium can safely take one powdered packet in their water, juice or tea every two hours until bowel tolerance is reached. Magnesium is also available topically for those with sensitive digestive systems at www.immunematrix.com.

Milk of magnesia and magnesium citrate are used as laxatives in hospitals and nursing homes. This means that the amount of magnesium in these products is not as absorbable into our cells and therefore serves the function of acting as a laxative. For obvious reasons this type of product is not good to take when one is trying to build up their magnesium stores.

If one is seeking to boost energy, or has been told they have mitochondrial disease or are suffering from chronic fatigue, fibromyalgia, lyme disease or a chronic viral infection, then taking magnesium along with malic acid (extracted from apples), an important metabolite in the Kreb’s cycle responsible for making ATP would be helpful. Malic acid also helps the body eliminate aluminum. Therefore, you should consult an experienced health care provider, one experienced in heavy metal chelation and liver detoxification pathways to determine your optimum dosage. They should be aware of signs of liver detoxification pathway problems to ward of symptoms that could arise from the inability to eliminate heavy metals and signs of drainage problems associated with toxic congestion.

Foods high in magnesium:

Below is a food chart listing magnesium content of food. Some of the best foods high in magnesium are sunflowers, topping the list, followed by wheat germ, and cashews! Legumes, nuts such as almonds, dark-green leafy vegetables, cocoa, dried fruits, shellfish, wheat bran, brewer’s yeast, barley, millet, corn and beet greens are especially high in magnesium.

Magnesium Content of Foods

Type of Food	Food	Serving Size	Milligrams Magnesium
Nuts and Seeds
	Almonds, dried	2 oz	168
	Brazil Nuts, Dried	2 T	128
	Cashew Nuts, Dry Roasted	2 oz	148
	Coconut, Dried	2 oz	52
	Flax Seed	2 T	70
	Peanuts, Dry Roasted	2 oz	98
	Peanut Butter, Natural	2 T	51
	Pumpkin Seeds, Dried	2 oz	304
	Sesame Seeds, Whole, Dried	2 oz	64
	Sunflower Seeds, Kernels, Dried	2oz	200
	Walnuts, Black, Dried	2 oz	114
	Watermelon Seeds, Dried	2 oz	292
Leafy Greens
	Chard, Boiled	1/2 cup	76
	Collard Greens, Boiled	1/2 cup	26
	Kale, Boiled	1/2 cup	12
	Spinach, Boiled	1/2 cup	79
	Spinach, Raw	1 cup	44
	Turnip Greens, Boiled	1/2 cup	16
	Seaweed, Kelp	3.5 oz	121
	Seaweed, Spirulina, dried	3.5 oz	195
Grains
	Barley, Pearled, Cooked	1/2 cup	17
	Barley, Whole Grain, Cooked	1/2 cup	61
	Corn, Yellow, Cooked	1/2 cup	26
	Quinoa, Cooked	1/2 cup	89
	Buckwheat Groats, Cooked	1/2 cup	51
	Millet, Whole Grain, Cooked	1/2 cup	53
	Oats, Bran	1/2 cup	96
	Oats, Whole Grain, Cooked	1/2 cup	56
	Oatmeal, Quick, Regular, or Instant, Cooked	1/2 cup	56
	Rice, Long Grain Brown, Cooked	1/2 cup	42
	Rice, Long Grain, White, Cooked	1/2 cup	13
	Rice, Wild, Cooked	1/2 cup	27
	Rye, Whole Grain	1/2 cup	35
	Wheat, Bran	2 T	10
	Wheat, Bulgur, Cooked	1/2 cup	29
	Wheat, Couscous, Cooked	1/2 cup	15
	Wheat Germ, Raw	1/4 cup	69
	Wheat Germ, Toasted	1/4 cup	91
Beans
	Adzuki Beans, Boiled	1/2 cup	60
	Black Beans, Boiled	1/2 cup	61
	Cowpeas (Black-eye). Boiled	1/2 cup	43
	Great Northern Beans, Boiled	1/2 cup	44
	Green Snap/String Beans, Boiled1	1/2 cup	16
	Green Peas-Boiled	1/2 cup	16
	Hummus	1/2 cup	36
	Kidney Beans, Red, Boiled	1/2 cup	40
	Lentils, Boiled	1/2 cup	36
	Lima Beans, Boiled	1/2 cup	41
	Navy Beans, Boiled	1/2 cup	54
	Pinto Beans, Boiled	1/2 cup	48
	Soybeans, Boiled	1/2 cup	74
	Tofu, Raw	1/2 cup	127
	Tempeh, Cooked	1/2 cup	58

Miscellaneous
	Blackstrap Molasses	2 T	86
	Chocolate, Unsweetened	1 oz	88
Fruits & Vegetables
	Acorn Squash, Baked	1/2 cup cubes	43
	Apple, Raw w Skin	1 medium	6
	Avocado, California	1 medium	70
	Avocado, Florida	1 medium	104
	Banana	1 medium	33
	Beets, Boiled	1/2 cup	31
	Blueberry	1.2 cup	4
	Broccoli, Boiled	1/2 cup	19
	Cantaloupe	1/2 cup pieces	9
	Carrots, Raw	1 Medium	11
	Cauliflower, Boiled	1/2 cup	17
	Cucumber, Raw	1/2 cup sliced	6
	Dates, Dried	5 dates	15
	Grapes	1/2 cup variety kinds	3
	Kiwi	1 medium	23
	Mango	1 medium	18
	Mushrooms, Boiled	1/2 cup, pieces	10
	Okra, Boiled	1/2 cup, sliced	46
	Onions, Boiled	1/2 cup	11
	Orange	1 medium navel	15
	Peppers, Sweet, Raw	1 cup, chopped	10
	Potato, White, Baked w Skin	1 potato	55
	Potato, White, Baked w/o Skin	1 potato	39
	Potato, White, Boiled w/o Skin	1 potato	26
	Potato, Sweet, Boiled w/o Skin	1/2 cup mashed	16
	Strawberry	1/2 cup	8
	Tomato, Raw, Ripe	1 tomato	13
	Tomato, Boiled	1/2 cup	16
	Watermelon	1/2 cup	8
	Zucchini, Boiled	1/2 cup sliced	19
Flesh
	Beef, Brisket, Braised	3.5 oz	24
	Beef, Ground, Lean, Broiled well done	3.5 oz	24
	Beef, Tenderloin, Lean, Roasted	3.5 oz	30
	Chicken, Dark Meat, w/o Skin, Roasted	3.5 oz	23
	Chicken, Light Meat, w/o skin	3.5 oz	27
	Seafood, Halibut, Baked/Broiled	3 oz	78
	Seafood, Salmon, Sockeye, Baked/Broiled	3 oz	20
	Seafood, Shrimp, Boiled	3 oz	29
	Seafood, Tuna, Skipjack, Baked/Broiled	3 oz	37
	Ham, Roasted	3.5 oz	17
	Turkey Breast, Smoked	3.5 oz	22
Dairy
	Milk, Cow, 2%	8 oz	33
	Milk, Nonfat	8 ox	28
	Milk, Goat	8 oz	34
	Milk, Soy	8 oz	45

Sources: Bowes and Church’s Food Values of Portions Commonly Used, Sixteenth Edition; Food Processor for Windows [Nutrition Analysis Software]. Version 7.60. Salem, OR: ESHA Research; 2000 Dec; USDA Nutrient Database.

We recommend that you become aware of foods that make you acid and what an acid diet is. (Please see our other blog articles.) Choose more alkaline producing foods. Try to drink lemon water sometime during the day to alkalinize yourself between meals. Begin to add more foods high in magnesium to each of your meals! Get tested for your intracellular magnesium ratios, especially if you suffer from any medical condition because there is much you can do within your own lifestyle to improve your symptoms and alter the course of your condition. Become aware of what you find stressful in life and try to remember that no amount of stress is worth the price of your health. Remember that what you do on a daily, weekly, basis has a significant impact on your body’s health.

Don’t be hard on yourself when you try to make positive changes. Remember that it takes 6 weeks to develop a habit! Decide to make one change at a time to your lifestyle, whether it is the reduction of soda from 3 drinks per day to only one for this week, or its entire elimination if you can. Give yourself weekly goals. Most importantly, when you try to eliminate a bad lifestyle habit, remember to replace it with a good one. Therefore, don’t just say that you are eliminating soda. Have a plan on what you will do in its place, otherwise you will find yourself ordering out of habit that soda because you can’t think at that moment what would be better for you to have.

Small steps lead to big changes. Don’t let a silent magnesium deficiency undermine your health, make an existing medical condition worse, or lead you to the necessity of becoming drug dependant for hypertension or osteoporosis when lifestyle changes and proper mineral balance can divert you from developing these conditions to begin with!

Please note:
Information on this site is provided for informational purposes only and is not intended as a substitute for the advice provided by your physician or other healthcare professional. You should not use the information on this site for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment.

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HOW MUCH MAGNESIUM DO WE NEED?

2010/06/20
Published

Part 5 of 6 (The Magnesium Deficiency Epidemic)

In Parts 1 and 2 we discussed why most of us are magnesium deficient and those lifestyle factors that cause us to burn magnesium at a faster rate. In Parts 3 and 4 we discussed why magnesium plays a crucial role in our staying healthy and energetic. We also learned which conditions are made worse with magnesium deficiency and how magnesium deficiency can play a central role in our developing other conditions. Here we will discuss how to determine our relative magnesium needs and how to get tested for intracellular magnesium. Empowered with this knowledge, you will be able to begin to restore the mineral balance so crucial to proper metabolic function.

Western medicine tests only for serum magnesium, the magnesium moving in your bloodstream, and this is not tested routinely! By the time your serum magnesium levels are low, your intracellular magnesium levels can be dangerously low, especially in heart muscle. One of the reasons serum magnesium is not routinely tested in one’s routine CBC panels is because low magnesium alone is not diagnostic for a disease. However, we know that low magnesium levels plays a crucial role creating certain disorders and in making many diseases worse.

Magnesium is nearly undetectable in your blood, ranging from 1.7-2.4mEq/litter, as opposed to its cousin, sodium, at a whopping 140mE/liter! Total body magnesium is not reflected in serum magnesium, neither is intracellular magnesium! Less than 1% of total body magnesium is found in the serum or blood plasma! Interesting to note is that most of our magnesium is stored in our brain, our heart and skeletal muscle. There has been no research confirming any correlation whatsoever between serum magnesium levels and the levels of magnesium stored in heart tissue! Now you can begin to see why serious problems can develop with chronic depletion of this essential mineral.

People with normal serum magnesium can still have depleted total body magnesium. IntraCellular Diagnostics, Inc.™, has a test called EXATEST™, that involves simply taking a scraping from the inside of one’s mouth and sending the sample to them. It tests intracellular minerals magnesium/calcium, phosphorus/calcium, potassium/magnesium, potassium/calcium, potassium/sodium, phosphorus/magnesium ratios and the ions, magnesium, calcium, potassium, phosphorus, sodium, and chloride. Test kits can be ordered from www.immunematrix.com at their online store.

With certain conditions such as chronic fatigue, many such patients may test normal on serum magnesium but have continued exhaustion until intracellular magnesium stores and its ratios with other essential minerals are replenished. Sometimes patients will only respond to magnesium injections or intra venous therapy. Other key supplements the chronic fatigue patient needs to add are B12, C, E, beta carotene, CoQ10, and d-ribose.

How much magnesium do we need?

It has been estimated that the average western world’s intake of magnesium is between 200-300mg/day with only half that absorbed! With increased environmental and food toxins needing to be removed by the body, the stress of modern life and our acidic bodies, we have an ever present need for a constant supply of magnesium. For those who like the apparent safety margin of computing their magnesium requirements, the chart below is a rough guideline for calculating one’s daily magnesium needs. The first two rows are normal daily magnesium requirements which by modern living standards from stress, the average diet, the bioavailability of magnesium in our food and our acid states should be considered low for our actual needs!

CALCULATING DAILY MAGNESIUM NEEDS:

Milligrams Per kilo body weight	body weight	Total milligrams magnesium
8-10	70 kilo	560-700 mg
3.5-4.5	150lbs	525-675 mg
13-15 for loss factors	70 kilo	910-1050mg
13-15 for loss factors	150lbs	1950-2250mg
Maximum 15	70 kilo	1050mg
Maximum 15	150 lbs	2250mg

Using the chart above, if you weight 150 lbs and want a moderate dose of magnesium, then you multiply your weight of 150lbs times 3.5 to 4.5, giving you a total daily milligram dose of 525-675mg.

However, most of us are already deficient in magnesium from an intracellular standpoint. Many of us suffer additional conditions that induce further depletion of magnesium or have magnesium deficiency symptoms! If so, you can use the “loss factor” calculations in the table above to find out a higher range to take.

Break the doses up into 3 or 4 and take them throughout the day. Smaller and more frequent dosages have proven to increase absorption by as much as 29% when compared to taking the entire dose at once. (Heaney, RP et.al. J of Bone and Mineral Research, 5:11;1990 p. 1135-1137)

It is also helpful to take your magnesium with other supplements or with food. However, if you are taking iron supplements, magnesium interferes with the absorption of iron! You need to take iron and magnesium 2-3 hours apart from each other.

Proper dosing without testing for intracellular magnesium ratios is not possible. You cannot determine if you have sufficient intracellular magnesium based on bowel tolerance symptoms. Bowel tolerance is the term used in taking vitamin C and magnesium. Your body absorbs both vitamin C and magnesium and when it cannot absorb anymore, it purges what it cannot absorb through your bowels, the stool. To assume that once you have reached bowel tolerance you have sufficient magnesium is incorrect! If you have bad intestinal absorption or intestinal inflammation or problems with cell membrane nutrient transport, then your body may not be able to get the magnesium into the cells and you will reach bowel tolerance sooner. But remember this does not necessarily mean you have sufficient intracellular magnesium.

Determining one’s magnesium needs is not quite an exact science because stress, our diet and daily needs fluctuate. In addition, the body takes time to deliver magnesium to where it is needed in our cells and tissues. It is also good to become familiar with your body’s signs if you are unable to test for intracellular magnesium. Do you suffer constipation? If so, consider magnesium deficiency as your primary concern and build up to the maximum dose spread out during the day, even as often as every 2 hrs until you have a bowel movement and your bowel movements begin to approach normal consistency. If your bowel movements become unformed and loose, back off on your dose the next day, and monitor your dose daily in this way. Therefore, you do not have to fear becoming toxic from taking in too much magnesium.

If you have kidney disease, work with your primary care provider in determining your maximum magnesium intake. However, getting to know your body’s signs and needs for magnesium are essential. Constipation, tight neck and shoulder muscles, leg and foot cramps are all red flags to begin to take magnesium, especially upon waking in the morning and preferably with a glass of warm water. If your stools tend to be hard, then you can definitely benefit from a magnesium supplement.

Does your body feel stiff, with stiff muscles or tendons? Do you have chronic inflammation, sugar metabolism issues, low energy, or have problems with insomnia or restless sleep? Magnesium will be the first thing to balance to improve these symptoms because they are all made worse with magnesium deficiency.

Finding your proper dosage will take some time in getting to know your body and what it is currently going through. Episodes of stress, having to take medications you have not taken before, eating too many refined carbohydrates or drinking a lot of alcohol will all cause acute depletions in your magnesium, causing your daily dose requirements to vary. If you have one or several of the chronic conditions listed above, then you would be well advised to work with a medical practitioner knowledgeable in reading organic acid and mineral lab findings to interpret your body’s metabolic needs for essential minerals and to insure you are getting a proper balance of your minerals.

Be aware also that as you replenish your cellular magnesium stores, your need for l-tryptophan, melatonin, St. John’s Wort, insulin, sleep medications, anti-depressants, cholesterol lowering drugs, thyroid medication, anti-hypertensive drugs and diuretics, osteoporosis medications will change. You will need to monitor or reduce and in some cases eliminate the drugs as your body goes back into mineral balance. Always work with an experienced medical practitioner knowledgeable about testing and weaning you off of your prescription medications.

Part 6 will discuss what type of magnesium to take and how you can choose foods high in magnesium as part of your healthy lifestyle.

Please note:
Information on this site is provided for informational purposes only and is not intended as a substitute for the advice provided by your physician or other healthcare professional. You should not use the information on this site for diagnosing or treating a health problem or disease, or prescribing any medication or other treatment.

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SOME CONDITIONS CREATE MAGNESIUM DEIFICIENCY

2010/06/18
Published

Part 4 of 6 (The Magnesium Deficiency Epidemic)

In Parts 1 and 2 we discussed why most of us are magnesium deficient and those lifestyle factors that cause us to burn magnesium at a faster rate. In Part 3 we discussed why magnesium plays a crucial role in our staying healthy and energetic. We also learned which conditions are made worse with magnesium deficiency and how magnesium deficiency can cause us to develop other conditions. Here, we will discuss more conditions and how they create specific needs for magnesium and how ignoring the depletion of magnesium can put us in harms way. Armed with this knowledge, you will be able to begin to restore the mineral balance so crucial to proper metabolic function.

The elderly:

The elderly tend to eat less, drink less water, eat more processed foods and take diuretics for blood pressure regulation. This puts them at peculiar risk for deficiencies in total body magnesium. It is also a known fact that the elderly eat less magnesium containing foods. Is it no wonder why constipation and cardiovascular deaths, and leg cramps are epidemic among the elderly?

Pregnancy and magnesium

Pregnancy increases the mother’s need for magnesium and calcium. Having multiple pregnancies increases the woman’s risk for osteoporosis and hyperparathyroidism of pregnancy. Toxemia in pregnancy, and postpartum heart problems increases one’ chances of blood clotting because of magnesium deficiency. The stress of childbirth and the presence of preeclampsia increases the mother’s draw of magnesium. Magnesium infusions were found to decrease the incidence of stroke and other thrombolytic events associated with these complications from pregnancy.

Magnesium deficiency and “sticky blood”

Sticky blood is a common term for having red blood cells that tend to stick together, called rouleau. Sticky blood is not a good thing. Oxygen transport suffers as does nutrient transport. However, it dramatically increases one’s chances for stroke, because the blood forms mini clots in the body.

What causes sticky blood? Eating foods that we have become immunologically sensitized to, or have developed an allergy to, or foods that react negatively to receptor sites on our red bloods cells now classified as incompatible with our genetic genotype™ will accelerate the formation of sticky blood. Having insufficient digestive enzymes to digest one’s food, and individuals challenged by sugar metabolism issues, having trouble breaking down their carbohydrates, or problems with insulin resistance will tend to have sticky blood. Individuals with fatty livers, high cholesterol, and atherosclerosis also suffer from sticky blood. Women taking hormones, whether on birth control pills or for menopause, are at higher risk for sticky blood.

Magnesium deficiency accelerates the rate in which red blood cells tend to stick together, making all the above conditions worse!

Insulin resistance, Syndrome X

Insulin resistance, Syndrome X, having any type of sugar sensitivity or sugar metabolism problem such as reactive hypoglycemia, or low blood sugar, or low cortisol or adrenal fatigue causes the same problems of burning more magnesium at a faster rate to accommodate for the problems with sugar metabolism. The body needs magnesium to use insulin properly, helping it convert glycogen to glucose! Magnesium deficiency is prevalent among diabetics. A poll conducted by the American Diabetes Association found that 99% had not been advised by their health care practitioner about magnesium deficiency when over half were taking diuretics for blood pressure control and had a history of heart disease in the family!

Diabetes and magnesium:

Osteoporosis is a common complication of insulin dependent diabetes! Low serum magnesium levels are common in juvenile diabetes. Elevated glucose increases magnesium excretion in the urine. Insulin is necessary for the cellular uptake of magnesium. Insulin resistance makes proper magnesium uptake ineffective, contributing to the acceleration of osteoporosis among diabetics.

Menopause and magnesium:

Estrogen enhances the uptake of magnesium into soft tissue and bones. This can be one more reason why women of childbearing age are more protected from heart disease and osteoporosis. However, if estrogen gets out of balance, elevated estrogen levels coupled with low dietary intake of magnesium causes the body’s biochemistry to shift to increase the calcium ratio over the magnesium. The elevate calcium causes increased fibrin formation leading to the development of clots, and the wasting of bone seen in osteoporosis. Taking calcium when one does not know if they have elevated estrogens will increase their risk for stroke, blood clots, kidney stones, bone spurs and osteoporosis even more! In addition, there is much to suggest that taking magnesium regularly is protective against the formation of clots and arteriospasms that can induce heart attack! Therefore, taking additional or even high dose calcium when you do not know your level of intracellular magnesium and you do not know what your ratio of calcium to magnesium can accelerate osteoporosis, and leading you quicker to stroke.

Osteoporosis and magnesium:

Estrogen deficiency, because of the loss of progesterone in menopausal women, and the ratio of estrogen to progesterone in the body (when estrogen remains elevated in ratio) results in reduced magnesium absorption. Insufficient magnesium in turn affects osteocytes (depressing the Mg-dependent ATP H+K+ pump) causing reduced bone formation and is a leading mechanism of osteoporosis in menopausal women! Interesting to note is that irrespective of the type of osteoporosis (senile osteoporosis, diabetic osteoporosis, alcohol associated osteoporosis and non-alcoholic cirrhosis induced osteoporosis) all forms showed low magnesium in the bone cortex. This resulted in an excessive acid state of bone extracellular fluid which in turn inhibited bone osteocytes from proper bone formation.

Parathyroid, imbalances in calcium and magnesium ratios:

Unfortunately, with all the focus on taking calcium, little focus is on the consequences of having an imbalance in one’s calcium to magnesium ratio! Taking more calcium than magnesium interferes with magnesium absorption because calcium and magnesium share the same intestinal absorption pathway!

Three possible causes can exist for low calcium aka hypocalcemia which would prompt one’ doctor at first glance to simply recommend higher doses of calcium. Hypocalcemia can be due to the impaired release of parathyroid hormone (PTH). Hypocalcemia can also result from resistance from bone and kidney to PTH and/or defects in the vitamin D synthesis pathway.

It has been found that reversing hypocalcemia happens NOT with increasing your calcium but with magnesium therapy! Magnesium therapy has also been shown to increase one’s responsiveness to vitamin D and PTH! Calcium on the other hand, would continue to tip this out of balance and push the patient into osteoporosis because it is not properly balanced with sufficient magnesium.

Estrogen keeps the parathyroid hormone in check. With loss of estrogen and this can occur without symptoms until it’s advanced, parathyroid hormone’s action goes unchecked leading to increased bone resorption, postmenopausal hyperparathyroidism and osteoporosis. The mechanism is believed to involve magnesium. Low estrogen means low absorption of magnesium which in turn increases calcium loss. Restoring magnesium reverses parathyroid hyperplasia and bone loss.

Women who enter menopause without the tormenting hot flashes still need to have their estrogen levels checked before they are told they have osteoporosis or hyperparathyroidism.

Magnesium also optimizes cacitriol levels along with optimizing vitamin D synthesis, all of which are estrogen dependent! It is an intricate chain reaction and reaffirms that proper hormone balance is essential over the oversimplified suggestion that all you need is more calcium! Estrogen (estrone, estradiol, estriol), progesterone, di-hydroxy-testosterone, leutinizing hormone (LH), parathyroid hormone (PTH), 25(OH)D3, serum magnesium, calcium, all should be checked before anyone takes a calcium supplement. To increase one’s dietary calcium could push you faster into osteoporosis if your magnesium, vitamin D and estrogen levels are also out of balance!

Heavy metal toxicity and chelation:

Magnesium is essential to fuel the liver’s key detoxification pathway. It uses a key amino acid, methionine. Insufficient magnesium means we are unable to bind heavy metals and excrete them through our kidneys and bowels. This is how magnesium protects our cells from the damaging effects of mercury, lead, cadmium, beryllium and nickel as well as many other toxins that the liver needs to eliminate. When the heavy metals cannot be bound and excreted by the liver, they become deposited into tissues such as the brain. This is a suspected mechanism for the formation of Alzheimer’s, Parkinson’s, and multiple sclerosis. It is also a suggestive mechanism for aggravating conditions such as autism, OCD, chronic fatigue, lyme disease, insomnia, anxiety disorders, hypertension, and many other conditions.

In our next article, Part 5, we will discuss how to determine our relative magnesium needs and how to get tested for intracellular magnesium. Empowered with this knowledge, you will be able to begin to restore the mineral balance so crucial to proper metabolic function.

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WHY IS MAGNESIUM SO IMPORTANT?

2010/06/16
Published

Part 3 of 6 (The Magnesium Deficiency Epidemic)

In Parts 1 and 2 we discussed why most of us are magnesium deficient and those lifestyle factors that cause us to burn magnesium at a faster rate. Here we will discuss why magnesium plays a crucial role in our staying healthy and energetic. We will learn what conditions are made worse with magnesium deficiency and how magnesium deficiency can cause other conditions. Armed with this knowledge, you will be able to begin to restore the mineral balance so crucial to proper metabolic function.

Magnesium is used in over 300 enzymatic processes in our body! Magnesium helps our body to manufacture ATP, our cellular energy. Individuals that feel weak and tired may be suffering “mineral deficiencies”, especially calcium, potassium and magnesium which will inhibit the production of our energy molecule ATP!

ATP also drives the cell membrane pumps that transport magnesium into the cell. Therefore, a vicious cycle can be created by magnesium deficiency from the lack of sufficient ATP synthesis and the resulting lack of cell membrane potential inhibiting the transport of nutrients across the cell membrane. Nutrient absorption, enzyme reactions, uptake and release of hormones, neurotransmitters, and the usage of potassium and calcium among other nutrients across the cell membrane can be inhibited as a result.

Besides nutrients moving across the cell membrane, oxygen is moved across the cell membrane with magnesium as the key cofactor. This helps to dilate blood vessels. With magnesium opposing the contractile effect of calcium, proper magnesium stores help to relax muscle, especially the muscle lining blood vessels. This can play a crucial role in lowering blood pressure and reducing asthma attacks. This same mechanism allows magnesium to neutralize a cell membrane helping to calm muscles. This is important in preventing cramping, spasms and maintaining muscle tone, especially in the heart! This is why deficiencies of intracellular magnesium can result in arrhythmias, muscle cramping, uterine contractions, and intestinal cramping and spasms. Magnesium also helps to calm the excitability of nerves which when over excited agitate the heart and push us into stress releasing hormone production.

Magnesium also acts as a cofactor in the sodium/potassium cell membrane pump which is ATP dependent! Improper function of this sodium/potassium pump with insufficient magnesium prevents the proper balance of electrolytes, even if you take them in!

Imbalanced ratios of calcium over magnesium will cause a host of problems. However, magnesium’s check on calcium helps to balance the release of neurotransmitters in the brain. Therefore, imbalances caused by taking too much calcium when you are low in magnesium can push your brain chemicals out of balance as well as increase your cholesterol and cause osteoporosis!

Magnesium deficiency pre-disposes you to:

Sudden death, cardiovascular disease in the form of atherosclerosis, arteriosclerosis, vascular spasms, angina, hypertension, arrhythmias of extra beats or atrial or ventricular arrhythmias, decreased survival rate after heart attack, increased cardiovascular problems for the pregnant mom as the placenta and fetus drain the mother of her magnesium, decreased athletic performance in long distance runners and rowers, bodybuilders and bikers due to increased muscle cramps, constipation, defects in one’s ability to detoxify heavy metals and other metabolic toxins from the body, osteoporosis, psychotic behavior that includes auditory and visual hallucinations, depression, anxiety, agitation, and panic attacks, seizures, muscle tremors, intestinal spasms, migraines, spasms of the fallopian tubes, spontaneous miscarriage, infertility, restless leg, abdominal and intestinal cramping, spastic tendons, carpal tunnel syndrome, chronic fatigue, exhaustion, headaches, tight neck and shoulders, migraine among the most common disorder associated with magnesium deficiency.

If you are lucky to avoid becoming entrapped by one of the above conditions, then magnesium deficiency can still accelerate aging. People deficient in magnesium suffer higher rates of certain cancers and degenerative conditions, many described above. Magnesium deficiency is also associated with increased risk of metabolic syndrome, known as Syndrome X and plays a crucial part in the degenerative changes of diabetes and osteoporosis. This leads us to examine what diseases and conditions are made WORSE by magnesium deficiency.

Conditions associated with magnesium deficiency:

These conditions are all made WORSE with an intracellular magnesium deficiency and can all be improved by having optimum magnesium stores replenished: ADD/ADHD, Alzheimer’s, chest pain, angina, anxiety, arrhythmia, rheumatoid arthritis, osteoarthritis, asthma, autism, auto-immune disorders that cause allergies, low cortisol and adrenal fatigue, elevated cortisol, Hashimoto’s thyroiditis, a blocked thyroid, cavities, cerebral palsy, chronic fatigue syndrome, congestive heart failure, ischemic heart disease, heart attack, cardiac arrhythmias, high blood pressure, preeclampsia, alcohol withdrawal, alcoholism, chronic constipation, crooked teeth, depression, diabetes Type 1, diabetes Type 2, bulimia, anorexia, fibromyalgia, peptic ulcers, spontaneous miscarriage, spastic colon, Chron’s disease, Grave’s disease, ulcerative colitis, arteriosclerosis, high cholesterol, high triglycerides, hypoglycemia, infantile seizures, insomnia, kidney stones, cluster migraines, migraines in general, mitral valve prolapse, multiple sclerosis, muscle cramps, restless leg, muscle weakness, fatigue, myopia, obesity, osteoporosis, Parkinson’s disease, PMS, primary pulmonary hypertension, Reynaud’s syndrome, SIDS, stroke, Syndrome X, insulin resistance, thyroid disorders where low magnesium reduced T4, low or high thyroid conditions other than auto-immune, and including autoimmune thyroid conditions, intestinal mal-absorption, the elderly, pregnancy, heavy metal toxicity, burns over a significant portion of the body.

Let’s take a look at the following significant conditions and see how they cause magnesium deficiency and in turn make these conditions even worse!

1) Chronic pain

2) Surgery

3) Asthma

4) Irritable bowel, intestinal mal-absorption

5) Being elderly

6) Being pregnant

7) Having “sticky blood”

8) Insulin resistance, Syndrome X

9) Diabetes

10) Menopause, estrogen dominance

11) Osteoporosis

12) Taking too much calcium

13) Parathyroid imbalances

14) Heavy metal toxicity

Chronic pain

Any condition that causes chronic pain of any type, such as arthritis, fibromyalgia, lyme disease, carpal tunnel, migraine, back pain, neck pain, headaches, soft tissue traumas and burns, causes magnesium to be consumed at a faster rate. This is especially troublesome for fibromyalgia patients who suffer other metabolic imbalances. Careful attention to the type of magnesium they are taking and their relative ratios of calcium, phosphorous, and other core minerals with proper laboratory testing is essential to rebalancing intracellular magnesium and reducing the threshold of pain!

Surgery

Surgery in general causes stress, which induces an acid metabolic state. Magnesium is consumed to neutralize this acid state. If you add the pain after surgery, you add another source for burning magnesium during your recovery stage. Heart surgery is a particular red flag for watching intracellular magnesium values, especially since increased magnesium increases the longevity and recovery rate for those who had suffered heart attacks.

Asthma

Bronchial asthma has long been associated with low intracellular magnesium. Magnesium has been reported to counter the toxic effects of asthma medications. Magnesium not only acts as a buffer to histamine and stress hormones elevated in this condition but its calming effect upon smooth muscle inhibits spastic contractions that make this condition chronic and life threatening.

Irritable bowels, intestinal mal-absorption

Any type of inflammation of the digestive tract will impact one’s absorption of minerals and other core nutrients. Celiac sprue, inflammatory bowel disease, irritable bowel, acid reflux, intestinal resections all cause magnesium mal-absorption. A bowel with insufficient probiotics, as well as a bowel overloaded with pathogenic bacteria, such as streptococcus, clostridia, pseudomonas, staphylococcus, and intestinal yeast and candida will reduce one’s ability to absorb magnesium.

Low magnesium to calcium ratios and low bone magnesium will accelerate bone thinning and demineralization, accelerating the process of osteoporosis.

Stomach aches and abdominal pains are made worse in children and adults with marginal magnesium stores irrespective of the state of their intestinal system. It was found that taking additional magnesium helped to buffer the biochemical effects of stress hormones, especially in those children and adults who tend to suffer from anxiety and greatly improved intestinal motility for better bowel performance.

Peptic ulcers improve for individuals on magnesium supplementation, as magnesium deficiency intensifies the ulcer by increasing the secretion of histamine, an inflammatory immune modulator. It might be wise for all individuals suffering from chronic inflammation to examine their magnesium supplementation and increase their dosages to buffer histamine reactions.

Part 4 will discuss the remaining listed conditions and how they create magnesium deficiency and will also go into detail on how you can determine what your magnesium needs are.

WHY ARE WE MAGNESIUM DEFICIENT?

2010/06/14
Published

Part 2 of 6 (The Magnesium Deficiency Epidemic)

In Part 1, we discussed a many lifestyle factors leading us toward chronic magnesium deficiency. Here we will discuss a few more significant lifestyle factors, the weekend warrior, overtraining, sweating without proper electrolyte replacement and the effects of stress in depleting us of our essential mineral, magnesium.

The Weekend Warrior, Overtraining

It has been found that exercisers that feel weak and tired are highly likely to be suffering from mineral deficiency. Magnesium is lost via sweat and can bring on fatigue, muscle cramps, impaired glucose and oxygen transport into muscle cells, especially the heart. Sweating from exercise or saunas, steam rooms, when done regularly require the regular replacement of magnesium. In severe cases, with extreme athletes, body builders and long distance runners, depletion of heart tissue magnesium can cause Sudden Cardiac Death (SCD), myocardial infarction, angina pectoris, and heart arrhythmias.

The mechanism of sudden death after a stressful event can be traced to magnesium depletion that causes oxygen depletion in the heart muscle, and increased arrhythmia from increased catecholamine output. Magnesium loss was the first electrolyte derangement seen even before potassium loss. Intravenous magnesium therapy has increased survival rates.

Without optimum “cellular magnesium” levels (our ATP/cellular energy synthesis) optimum muscle contraction and oxygen utilization suffers, sometimes with fatal consequences. Therefore, over-training, overexertion, excessive sweating, either done in one event or done repetitively, especially without sufficient electrolyte replacement will burn magnesium at a faster rate and send us into intracellular deficiency of magnesium.

A runner need not drop dead on the course of sudden cardiac death to be magnesium deficient. Sudden cardiac death strikes the youth and prime even post event when intracellular heart magnesium is not replenished. Overtraining, and not becoming aware of the state of one’s intracellular magnesium could be fatal as you might not have other magnesium deficient symptoms such as cramping of muscles to warn you of a problem!

In a treadmill study of 44 healthy male athletes and 20 untrained men, the athletes’ their average maximum oxygen consumption was higher, their work capacity increased 50% and they had lower lactate after exercise than the untrained men. This is to be expected. What was not expected was to find a correlation between oxygen consumption and serum magnesium. When magnesium was depleted, oxygen consumption declined along with endurance and performance. Therefore, magnesium’s role in facilitating oxygen delivery to muscles is significant.

Another interesting study was performed on marathon runners measuring their free fatty acid levels during a 26 mile race and their serum magnesium levels. They compared their values against an untrained runner who was given magnesium supplementation of 375mg/day for a week before the run. The marathon runners showed increasing levels of free fatty acids as they approached 26 miles (indicating increasing levels of stress perceived by the body and stress hormones released as a result) and corresponding decreasing levels of serum magnesium levels, but not with the untrained runner! Because he was talking magnesium, his body was able to burn the magnesium to ward of an increase in stress hormones. He had lower stress hormone excretion, less lactic acid build up and more magnesium to spare. The end result, he ended the race healthier metabolically than the marathon runners who did not take magnesium supplementation! (Pratt K, Moody ML, Cinlee RK, Rueddel H, Frnz KB; Changes in serum free fatty acids and magnesium during a marathon. Magnesium 4:207-208, 1985.

Another study found that the stress of marathon running had caused these runners to have increased platelet aggregation factor TXB2 levels as serum magnesium levels were depleted. TXB2 causes vasoconstriction as well as sticky blood. Clearly, magnesium replacement during runs are as or even more important than plain water to prevent dehydration during and after a race!

Additional silent damage, the consequence of magnesium deficiency, induced by strenuous exercise, leads to calcium overload, resulting in cell membrane lipid anti-per oxidative activity. In lay terms, this means magnesium deficiency increases one’s free radical activity, leading to increased stress on one’s heart muscle, leading to aggravation of all heart conditions. Free radical accumulation from extreme exercise and magnesium deficiency was buffered by taking vitamin E and magnesium. The fact that extreme athletes and those regularly engaging in strenuous exercise do not have a longer lifespan may be attributed to magnesium depletion leading to increased oxidative stress and metabolic induced inflammation which could be avoided by paying attention to one’s magnesium!

Therefore, even before we begin to push our bodies for strenuous exercise, if our tissue magnesium stores are low, we will notice more fatigue, decreased exercise capacity despite regular exercise. We will feel dragy, winded and have a hard time picking our energy up from exercise. If we continue to push our bodies, we will then suffer muscle stiffness, spasms or strains and sprains from the stiffness that results from low intracellular magnesium. Biochemically, we will increase our stress hormones even more when we are magnesium deficient, and suffer more free radical synthesis, increased cholesterol! and oxygen depletion to our heart muscle. However, our heart tissue can become deficient in magnesium before other tissues of the body. Thus we might not have any body symptoms to warn us of a more serious heart muscle deficiency. The consequences to the heart can be fatal. Beware the stressed executive that dies on his/her treadmill as this can be the silent vicious cycle of mineral depletion.

Stress

We all underestimate stress because we live in it daily and take it as part of our daily lives. But stress takes it’s toll on us. Stress, both physical and mental aggravation, frustration, irritability, causes you to burn magnesium at a faster rate. Stress makes your body more acidic. Magnesium is used to buffer that acid. Therefore, stress causes you to burn magnesium faster to neutralize the acid.

Our adrenals and nerves secrete stress hormones called catecholamines and corticosteroids, when under emotional or physical stress. Do you know when your body is releasing these stress hormones? No! Like using up the gasoline in one’s car, it’s a slow and steady drain. These stress hormones cause the loss of cellular magnesium leading directly to problems with cellular energy production, and skeletal and heart muscle performance that lead to blood clotting and heart arrhythmias.

There was a study comparing Type A and Type B individuals that found that Type A personalities excreted more stress hormones in response to noise and mental stress and depleted their magnesium faster than Type Bs! This explains the increased risk among Type A’s for mitral valve prolapse, hypertension, and cardiovascular disease. Becoming aware of our stressors, managing how we react to stress and increasing one’s magnesium will help to buffer us from daily stress.

The bad thing about stress is that as it deplets you silently of your magnesium, low intracellular magnesium causes the excretion of MORE stress hormones. Therefore, magnesium is protective in preventing excessive release of these stress hormones! In addition, adrenal stress that causes the adrenals to release the hormone epinephrine (our fight or flight hormone) burns intra cellular magnesium at such a fast rate that one quickly becomes depleted.

What causes our adrenals to release more epinephrine? Physical stress, as in strenuous exercise, strenuous training, runners, especially marathon runners and those suffering from prolonged emotional, familial, and work stress. Please see our other articles about cortisol function.

The stress hormones also signal the body to release free fatty acids as an energy source. However, there is a price to pay for this extra needed energy boost during times of stress. These free fatty acids bind and inactivate magnesium in your blood stream and heart, slowing down the transport of glucose and oxygen into muscles and prevent magnesium from being used by the Kreb’s cycle to make ATP as energy, using a more inefficient free fatty acid source for energy. Fatigue, cellular oxygen depravation especially of heart tissue, increased free radicals, loss of glucose transport, and our cholesterol ratios are thrown out of balance. We hit a wall energetically.

Imagine the typical stressed executive, by nature of his/her lifestyle is already burning magnesium at a faster rate because of their adrenal output of stress hormones. He wakes up and has a high acid breakfast of coffee, eggs and a muffin that consumed intracellular magnesium to neutralize the breakfast. He dashes to work out already feeling short on time. Then this driven executive goes to the gym and does a rigorous 30 minute treadmill run, sweating out magnesium and continuing to push his adrenals to excrete epinephrine for energy to keep up with his strenuous activity. If the night before, he had to entertain clients and had several alcoholic drinks (causing him to urinate extra magnesium) and he ate a large steak for dinner (high acid meal), then his lifestyle continues to deplete him of magnesium. If there was a work deadline pending the next few days, or this executive had a fight with his wife the night before or with his kids that morning before hitting the gym, his body is in peak demand for magnesium. Depending on the duration of his life stressors and duration of his acid diet, combined with his life stressors, it becomes no surprise when this executive drops dead on his treadmill from sudden cardiac arrest, in large part from severe depletion of myocardial intracellular magnesium.

If this stressed executive does not drop dead that morning, then continued stress hormones coupled with consumed intracellular magnesium cause calcium overload in the tissues. This will lead to heart arrhythmias and calcium deposits in blood vessels, accelerating atherosclerosis, the development of kidney stones and bone spurs, accelerating osteoporosis for men and women. It will push his cholesterol out of optimal range despite his efforts to eat a heart healthy diet!

Now that we know that our food and lifestyle predisposes us to magnesium wasting, what do we have to fear aside from sudden cardiac death with chronic depletion of magnesium?

Part 3 will discuss why magnesium is so essential to our health. It will also go into what medical conditions pre-dispose you to magnesium deficiency and discuss specific conditions and their mechanism of depleting us of magnesium, in turn making the condition worse!

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THE MAGNESIUM DEFICIENCY EPIDEMIC

2010/06/12
Published

Part 1 of 6

Why do we care if we are magnesium deficient? And how deficient do we have to be to start caring?! So what if we tend to have one bad habit that will deplete us of magnesium? Should we be waiting and looking for a specific condition or symptom(s) associated with magnesium deficiency before we do something? The purpose of these articles on magnesium is to wake us up to the significance that magnesium plays in our health. It gives us energy, prevents bone loss, osteoporosis, helps balance our hormones, and helps us with sugar metabolism issues. It helps us excrete heavy metals and other toxins. Most significantly, we hope this article wakes us up to magnesium’s key role in improving more common conditions that plague us that we take for granted as incurable or un-improvable, and lead us to the need to take blood pressure medications and osteoporosis medications in some cases and in other cases keep us drug dependent for lack of any other hope. We can even avoid premature death, if we pay attention to magnesium!

We suggest that you read the entire set of articles here on magnesium, then print it. Go back and highlight all things that pertain to you and add them up to see how many risk factors are pushing you or keeping you in a state of magnesium deficiency. Then get tested, start to optimize your intracellular magnesium and watch how your health begins to improve!

Why Are We Magnesium Deficient?

Our food source is deficient in magnesium. Fertilizers contain potassium and phosphorus. Both organic and regular farming practices use fertilizers. These fertilizers alter a plant’s ability to take in and store magnesium. Therefore, modern farming practices help to deplete our food supply of much needed magnesium to begin with.

How we prepare our food impacts the amount of magnesium we have to absorb. Food processing removes magnesium. Broiling, steaming, and boiling food in water leaches out more magnesium.

Our lifestyle depletes us of magnesium in too many ways! What we do on a daily and regular basis in terms of our lifestyle habits sets us up for mineral depletions and toxic exposures. It sets the course for our imbalances that lead to disease and premature death.

Let’s look at the principal lifestyle factors that lead us toward chronic magnesium deficiency:

1) Alcohol consumption

2) Coffee consumption

3) Refined carbohydrate and sugar consumption

4) Soda consumption

5) High fat consumption

6) Some prescription drugs

7) Hormone replacement therapy

8) Recreational drugs

9) Dieting

10) Liquid protein fasts

11) Weekend warriors, extreme athletes, overtraining, excessive sweating

12) Stress

Alcohol

Drinking alcohol of any kind causes significant loss of magnesium from our body through our urine. Alcohol increases urination of magnesium and is a number one factor in heart-rhythm abnormalities encountered with heavy drinkers. Habitual long term alcohol consumption leads a person into excessive magnesium excretion, intracellular magnesium deficiency results. Tremors, hallucinations, convulsions, hypertension, arrhythmias, osteoporosis, and sudden cardiac death can result. Magnesium therapy can easily reverse this.

Coffee

Coffee depletes our body of magnesium, B vitamins, L-lysine, making us more prone to stress. Coffee sets us up to become acidic, deficient in B vitamins and L-lysine, essential to keep viral infections suppressed (herpes, canker sores). Stress makes us need more B vitamins and makes us even more acidic. Being acidic causes us to need even more magnesium! The result is a vicious cycle of B vitamin deficiency, increased incidence of outbreaks in herpes, canker sores, chronic viral infections, and fatigue from loss of magnesium. Coffee alone is not bad. However, if you are already acidic, under lots of stress, living a modern lifestyle, or have hidden or chronic viral infections such as herpes, then you are not helping yourself with this habit.

Refined carbohydrates and sugar

Eating refined carbohydrates such as white sugar, processed food, high fructose corn syrup or processed flour (white flour) depletes our body of magnesium because we burn up our magnesium faster to metabolize the refined carbohydrates. These carbohydrates also make us more acidic and we use magnesium to buffer our acidic state, burning magnesium to put us back into a state of ph balance.

Sodas

Besides sugary drinks, fruit drinks filled with corn syrup, sodas and carbonated beverages deplete the body of magnesium and calcium stores by their chemical nature and by the fact that they make us acidic. It matters not weather they are diet or regular sodas. Caffeinated sodas cause even more depletion of magnesium. Sodas are a leading factor in our children developing osteoporosis by young adulthood.

High fat diets

High fat diets burn magnesium at a faster rate. When magnesium becomes depleted, the rate of plaque formation in the arteries accelerates! Magnesium deficiency alters fatty acid metabolism such that linoleic acid is converted to the high inflammatory arachidonic acid which will increase blood coagulation, meaning the blood will tend be more sticky. This leads to blood clots and strokes. This is reversed by magnesium supplementation to the extent that even triglycerides and very low density lipoproteins (VLDL) can be decreased. One study increased HDL by 27% after magnesium supplementation. Therefore, take your magnesium supplements with your burger and fries if you must have them!

Some prescriptions drugs

Some prescription drugs such as Cyclosporin deplete the body of magnesium. Taking extra “balanced” magnesium will be protective against the side effects of Cyclosporin.

Certain blood pressure medications cause excessive excretion of magnesium due to their diuretic effects. Switching medications from hydrochlorothiazides to a beta-adrenergic blocking agent such as propranolol can help to preserve excessive magnesium loss but also come with their own set of side effects. Therefore, magnesium supplements might be the better choice over switching one’s medications.

Other drugs known to deplete the body of magnesium are: amphotericin B, cisplatin, ethanol, gentamicin, pentamidine.

Recreational drugs

Taking amphetamines and cocaine are just plain bad, but one mechanism of sudden death is the depletion of intracellular myocardial magnesium.

Hormone Replacement Therapy

Women need estrogen to absorb magnesium! If there is insufficient magnesium present however, the calcium/magnesium ratio can shift out of balance where calcium dominates. There are no symptoms of this. Elevated calcium causes increased fibrin formation leading to the development of clots, and the wasting of bone seen in osteoporosis. Taking calcium when one does not know if they have elevated estrogens or does not know if their ratio of calcium to magnesium is elevated, will increase their risk for stroke, blood clots, kidney stones, bone spurs and osteoporosis even more! In addition, there is much to suggest that taking magnesium regularly is protective against the formation of clots and arteriospasms that can induce heart attack! Therefore, taking additional or even high dose calcium when you do not know your level of intracellular magnesium and you do not know what your ratio of calcium to magnesium can accelerate osteoporosis, and lead you quicker to stroke.

Dieting

Diet pills that are diuretics, or especially those that contain phentermine, or fenfluramine also deplete the body of magnesium stores.

Starvation diets: Studies of concentration camp survivors and those engaged in starvation diets to loose weight found that even with high magnesium supplementation for months, the stress hormones induced by starvation interfered with the uptake of magnesium for several months thereafter despite adequate magnesium supplementation. In addition, starvation diets often caused sudden cardiac death from severe depletion of heart magnesium. This is one mechanism for sudden death in those that suffer from anorexia.

Short term and long term fasting does cause magnesium loss but generally not in such extremes as to cause low intracellular magnesium which would lead to cardiac symptoms or sudden death. Another long term fasting study of three months showed an average loss of 20% body magnesium that resulted in the development of carpal tunnel spasms that were relieved by intravenous magnesium therapy.

Liquid protein diets can cause such acidity that significant intracellular magnesium is lost even in the presence of normal serum magnesium levels. Deaths by ventricular fibrillation resulted despite individuals supplemented with calcium and potassium. What was not detected was confirmed on autopsy that the heart lesions were caused by depletion of heart intracellular magnesium! Intracellular magnesium is never tested for in routine hospital or emergency visits! Magnesium had not been supplemented during the high protein fast! Again because it has been so difficult to test for low intracellular magnesium, and it is so easy to take additional magnesium supplements, a little knowledge about this underappreciated mineral could save a life!

Part 2 will discuss the remaining significant lifestyle factors that drive us toward chronic magnesium deficiency and can even cause sudden death!

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WHEN B VITAMIN METABOLISM GOES WRONG…..

2010/03/22
Published

The purpose of this article is to introduce you the concept of B vitamin metabolism, the effect the immune system can have in interfering with your B vitamin metabolism, how B vitamins impact detoxification and how problems metabolizing B vitamins aggravate certain conditions.

We all need and use B vitamins daily for survival. However, when we suffer from a chronic disease or inflammatory disorder such as Autism, Asperger’s syndrome, ADD, ADHD, OCD, depression, PMS, seasonal allergies, food allergies, environmental sensitivities, arthritis, acid reflux, diabetes, chronic fatigue, fibromyalgia, lyme disease, eczema, hives, itchy skin, brain fog, developmental delay disorders, chronic sinusitis, recurrent ear infections, irritable bowel, Crohn’s disease, celiac sprue, heavy metal toxicity, toxic teeth, chronic viral infections, mood disorders, and/or insomnia, our metabolism of B vitamins may not be functioning correctly. Traditional medicine looks at the levels of B vitamins in a patient and makes a HUGE ASSUMPTION that if the level of a vitamin is low, it is because they are deficient in that vitamin AND that they are not taking enough of that vitamin from food or supplementation. This is not necessarily true! It completely ignores the issue of how the body metabolizes B vitamins and how the immune system can become triggered to block the body’s synthesis and degradation of B vitamin metabolites.

HOW DOES THE IMMUNE SYSTEM INTERFERE WITH THE SYNTHESIS OR DEGRADATION OF B VITMAINS?

If your immune system recognizes a B vitamin such as B12, then it blocks the usage of that vitamin to various degrees by treating it as a foreign invader. The immune system may blocking its usage, to various degrees, eliminating it from your body and making it appear as if you are deficient in that vitamin. The degree of immune interference with that vitamin varies depending on the degree and type of inflammation that patient is suffering from. If the immune system recognizes a metabolite or a number of metabolites in the synthesis or degradation of B vitamins, then you will have a proportional inhibition either in the synthesis of a B vitamin or degradation in that vitamin.

B VITAMINS ARE NEEDED TO RUN DETOXIFICATION PATHWAYS

The liver performs over 40,000 metabolic processes in the body. A handful of these involve detoxification. The most significant pathway is called the methylation pathway for many reasons. This pathway is new on the frontier of understanding our genetic and metabolic connection to detoxification. Certain genetic variations in this pathway make it more difficult for some individuals to bind and excrete toxins. For purposes of this article, B6 and B12 and 5-tetra-hydroxy-folate are essential to run this pathway. Think of them as key ingredients in a recipe. Without them, the bread does not rise and you do not get the desired result. If your immune system interferes with the usage of an ingredient needed to make a B vitamin such as B12, then the availability of that vitamin to fuel the detoxification pathway will be hindered in direct proportion to the degree of immune system interference. If your immune system hinders the degradation of a B vitamin in the liver, then the toxic load to your liver increases and the B vitamin metabolites act as fuel to increase inflammation to specific body receptor sites such as the brain, nerve tissue and neurotransmitter synthesis, and skin.

The most significant challenges seen involving the usage of B vitamins occurs in the autism spectrum of disorders. The child’s immune system is on hyper alert and with various treatment programs, large quantities of B vitamins are given to the child by many doctors. The parents may begin to see an increase in symptoms when B vitamin dosage is increased. This can also occur when the level of glutathione or other heavy metal chelators are given to the child. These chelators increase the body’s demand for key B vitamins and can aggravate immune system interference with B vitamin synthesis and degradation in the body, sometimes derailing the body’s ability to use B vitamins. These children do need more B vitamins when pushed to detoxify but their immune system does not allow for this increased demand. This occurs in addition to any genetic defects in their detoxification pathways called SNPs.

In other autism spectrum cases, increasing the dosage of B vitamins increases the neurological inflammation present in the brains of these children and their neurological symptoms increase. What has also been known to occur is that the immune sensitivity to the B vitamin is also linked to an immune recognition with a neurotransmitter(s). As a result you see, more aggression, more head banging, & shorter attention span. They seem to regress. This is a huge sign that there is a metabolic block to pushing their body to metabolize more B vitamins.

Many other inflammatory condition involve this same mechanism of action in preventing a patient from taking and using their B vitamins. The more the inflammation, the worse the reactivity can be to the B vitamin. As a result skin conditions can worsen in eczema and hives. Chronic fatigue and fibromyalgia patients can suffer more fatigue and increased pain and body aches. Those with toxic teeth or heavy metal toxicity can suffer body stiffness, body pain, tight muscles, headaches, even to the point of migraine. The frequency of irritable bowel and other digestive disorders can peak.

Immune Matrix has a proprietary protocol for testing and treating these complex detoxification pathways. The result is that the patient is able to begin to use B vitamins. Smaller dosages are needed, taxing the liver less. Neurotransmitter synthesis and performance improves. Heavy metal excretion improves. Behavior of the child begins to improve such that teachers begin to take note and ask the parent what they are doing to change their child. Laboratory values for B vitamins normalize. Immune cell interference on detoxification pathways declines and patients are able to excrete toxins without complications. Their excretion of heavy metals increases. Mental clarity and energy begin to improve from improved levels of B vitamin metabolism.

Any chronic inflammatory condition can be aggravated by immune cell recognition of B vitamin metabolites. This results in your being deficient in your usage of B vitamins and causes you to become more toxic from taking B vitamins because they cannot be eliminated from the liver as easily.

Most B vitamins on the market are synthetic. Synthetic B vitamins are a molecular opposite of the natural form we need in our body. As a result, this synthetic B vitamin has to be “degraded”, broken down in the liver. It then must be converted to a natural form of B vitamin. This conversion is never 100%. Therefore, the conversion of synthetic B vitamins always increases one’s toxic load. If you have immune cell interference in the conversion, either in synthesis or degradation, then your toxic burden increases. Your tolerance to B vitamins decreases! This is why many people react to their vitamins!

Chronic inflammatory conditions such as autism, arthritis, eczema, chronic fatigue, fibromyalgia, Hashimoto’s thyroiditis, Chron’s disease, celiac disease, psoriasis, ADD, ADHD, all tend to need more B vitamins. Inflammation depletes the bio-availability of B vitamins. Stress from inflammation depletes the bio-availability of B vitamins. Increased toxicity depletes the body of B vitamins. Life stresses affect these individuals more, because of their inefficient B vitamin metabolism. Diet also depletes the body B vitamins! Especially coffee, nuts, gelatin, pineapple, chocolate. Chronic viral infections deplete the body of B vitamins. Now you can see how the body is drained of B vitamins necessary for efficient detoxification. This does not even allow for the usage of B vitamins for neurotransmitters and nerve repair, stress management, and skin repair!

B vitamins are essential to:

1) Detoxify efficiently

2) To make neurotransmitters

3) To repair nerve cells and neurons in the brain

4) To manage stress

5) To repair skin

When your immune system interferes with B vitamin degradation, synthesis or detoxification:

1) B vitamin metabolites accumulate in the liver increasing your toxicity

2) Hinder efficient detoxification of heavy metals & other toxins

3) Hinder repair of brain cells, allowing toxins to aggravate the brain

4) Hinder repair of nerve tissue in the body, allowing toxins to aggravate nerves in the body. This increases irritable bowel, increases pain sensation, numbness and tingling in the limbs, and aggravates insomnia, irritability, and mood.

5) You become more reactive to taking B vitamin supplements. You can have rashes, hives, feel shaky, heart pounding, irritable, etc.

6) You become unable to process other vitamins, tinctures, drugs, and supplements, because of increasing toxic load and inefficient detoxification metabolism. Some patients are unable to take what their doctors give them for this very reason.

WHAT CAN YOU DO TO IMPROVE B VITAMIN METABOLISM?

1) B vitamins are best absorbed when in the natural form from foods. In the United States those supplements that are not synthetic but food based have to list the foods on the bottle to show the basis in which the vitamins are extracted.

2) It helps to find out your genetic SNPs for the methylation pathway. You can contact Immune Matrix at 408-262-6900 to find out how you can be tested. This will help to determine whether you can handle methyl donors or need a different type of B vitamin supplementation.

3) You can be tested at www.immunematrix.com and have those pathways treated to make your methylation pathway more efficient. Immune Matrix will also determine if there is a cross-reaction going on between B vitamins, neurotransmitters and methylation, the classic triad that aggravates chronic inflammatory conditions.

4) Try to avoid a synthetic B vitamin and in its place, take a sublingual B12 and 5-tetra-hydroxyfolate. By limiting your B vitamins to these two for a period 30-60 days you can give your immune system a break and help provide the key detoxification catalysts. Be sure to take some form of magnesium (preferably with a mineral supplement that contains molybdenum). These two additional minerals are key ingredients that drive the methylation pathway making efficient detoxification possible.

5) Take smaller doses of your prescribed supplements and more frequently during the day if possible. Avoid taking B vitamins after 3p.m. as this can disturb your sleep.

6) Take one activated charcoal at night before bedtime to help absorb toxins the body is unable to bind. This minimizes the side effect one can feel from reacting to toxins that the body is unable to bind and excrete. Activated charcoal can cause constipation, therefore, take only one and only as needed.

7) Drink more water to help flush toxins through your bowels and urinary track.

As you are now beginning to understand, taking a vitamin because your lab test says you are deficient often does not take care of the deficiency. The body has a wisdom WHY it is deficient – usually there is a metabolic hindrance to using that substance. That metabolic hindrance can be from a genetic defect that can be bypassed with proper supplementation to side pass the defect. That hindrance can be aggravated by immune sensitivities to the vitamin or its metabolite. That hindrance can also be aggravated by immune cross-reactions with neurotransmitters and other metabolites which hinder B vitamin metabolism, excretion, or interaction with other neurotransmitters in the brain and nervous system. The dynamics are interrelated and therefore consulting with a health care professional experienced in reading labs in light of the dynamics of immune sensitivities and how they relate to one’s core detoxification pathways are often necessary with a more chronic inflammatory condition.

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